Insulin-sensitive Obesity: Lessons From Longitudinal Data (ISOS)
People who are overweight and/or obese usually are insulin resistant and so are at risk of type 2 diabetes. However, research has shown that some overweight and/or obese people remain insulin sensitive and healthy despite their weight.
The investigators hypothesise that insulin-sensitive overweight and/or obese people maintain their insulin sensitivity and metabolic health over time. The investigators also hypothesise that the preservation of insulin sensitivity will be determined by key metabolic factors.
|Study Design:||Intervention Model: Single Group Assignment
Masking: No masking
Primary Purpose: Other
|Official Title:||Insulin-sensitive Obesity: Prospective and Interventional Studies|
- Change in insulin sensitivity [ Time Frame: change in insulin sensitivity at follow up compared to 6 years ago ]Insulin sensitivity will be assessed in this current follow up study. This will be compared to insulin sensitivity data collected in this study cohort approximately 6 years ago.
- Change in anthropometry (weight, height, BMI, waist and hip circumference) [ Time Frame: Change at follow up compared to 6 years ago ]
- Change in total body fat and distribution [ Time Frame: Change at follow up compared to 6 years ago ]
- Change in fasting insulin, c-peptide, glucose levels [ Time Frame: Change at follow up compared to 6 years ago ]
- Change in HbA1c, 75g oral glucose tolerance [ Time Frame: Change at follow up compared to 6 years ago ]
- Change in fasting non-esterified fatty acids and lipids profile [ Time Frame: Change at follow up compared to 6 years ago ]
- Change in circulating adipokines, cytokines and hepatokines [ Time Frame: Change at follow up compared to 6 years ago ]
- Change in blood pressure [ Time Frame: Change at follow up compared to 6 years ago ]
|Study Start Date:||November 2013|
|Study Completion Date:||February 2016|
|Primary Completion Date:||February 2016 (Final data collection date for primary outcome measure)|
Experimental: Longitudinal follow up
Participant's metabolic parameters are followed up after approximately 6 years.
Other: Longitudinal study
Metabolic health, anthropometry, body fat distribution, liver lipid will be followed up in individuals previously studied at the Clinical Research Facility.
Please refer to this study by its ClinicalTrials.gov identifier: NCT02017210
|Australia, New South Wales|
|Garvan Institute of Medical Research|
|Darlinghurst, New South Wales, Australia, 2010|
|Principal Investigator:||Jerry R Greenfield, BSc(Med) MBBS PhD FRACP||Garvan Institute of Medical Research|
|Principal Investigator:||Dorit Samocha-Bonet, BSc(Hons) MSc(Hons) PhD||Garvan Institute of Medical Research|