French Observatory of Familial Hypercholesterolemia in Cardiology (FH Care)

This study is currently recruiting participants. (see Contacts and Locations)
Verified February 2015 by French Cardiology Society
Information provided by (Responsible Party):
French Cardiology Society Identifier:
First received: December 6, 2013
Last updated: February 12, 2015
Last verified: February 2015

The Family Hypercholesterolemia remains poorly diagnosed disease with an outlet sometimes suboptimal care. However, the Family Hypercholesterolemia exposes patients concerned at increased cardiovascular risk.

The frequency of familial hypercholesterolemia in cardiologic is little studied and remains unknown, and there is little data on the profile of patients, diagnostic methods and management.

Main objectives:

  • Establish a monitoring patients with hypercholesterolemia Family cardiology in France
  • Characterize the Family hypercholesterolemia in cardiology, including assessing the frequency of the most severe forms, which are at higher cardiovascular risk.

Familial Hypercholesterolemia

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: French Observatory of Familial Hypercholesterolemia in Cardiology

Resource links provided by NLM:

Further study details as provided by French Cardiology Society:

Primary Outcome Measures:
  • Frequency of the Family Hypercholesterolemia in cardiology [ Time Frame: 1 day ] [ Designated as safety issue: No ]
    Number of Family Hypercholesterolemia among patients with LDL-C> 1.9g / l without hypoglycemic treatment or> 1.6g / l in lipid-lowering therapy

Estimated Enrollment: 200
Study Start Date: November 2014
Estimated Study Completion Date: December 2023
Estimated Primary Completion Date: December 2022 (Final data collection date for primary outcome measure)
Family Hypercholesterolemia in cardiology


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

The study is proposed to cardiology services hospitals. Aged 18 or more, seen in cardiology (USIC, Hospitalization, Consultation), who agreed to participate in the observatory, and coronary patients who have LDL-c levels


Inclusion Criteria:

  • coronary patients
  • who agreed to participate
  • high LDL-c levels: * LDL-c> = 1.9g / l without lipid lowering treatment according to the diagnostic score of Family Hypercholesterolemia these coronary patients with LDL> 1.9g / l may possibly or probably be achieved Hypercholesterolemia Family.


* LDL-c> = 1.6g / l in lipid-lowering treatment, the reduction of LDL-c average expected under standard lipid-lowering therapy (statin alone) being 30-40% of these patients had therefore pretreatment levels greater than 2 g / l or greater than 2.5 g / l and may possibly or probably be achieved Family Hypercholesterolemia after the diagnostic score.

Exclusion Criteria:

  • Expressed refusal to participate in the observatory
  • Age ≤ 18
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT02013713

Contact: Albert HAGEGE 33(1) 43 22 33 33
Contact: Geneviève MULAK 33(1) 44 90 70 35

European Hospital Georges Pompidou Recruiting
Paris, France, 75015
Contact: Albert Hagège         
Contact: Geneviève Mulak    +33 (0)1 44 90 70 28   
Principal Investigator: Albert Hagège         
Sponsors and Collaborators
French Cardiology Society
  More Information

Responsible Party: French Cardiology Society Identifier: NCT02013713     History of Changes
Other Study ID Numbers: 12 449
Study First Received: December 6, 2013
Last Updated: February 12, 2015
Health Authority: France : CNIL (National Commission on Onformatics and Freedoms) - Authorization N°912411

Keywords provided by French Cardiology Society:
Family Hypercholesterolemia

Additional relevant MeSH terms:
Hyperlipoproteinemia Type II
Genetic Diseases, Inborn
Lipid Metabolism Disorders
Lipid Metabolism, Inborn Errors
Metabolic Diseases
Metabolism, Inborn Errors processed this record on October 06, 2015