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Effects of Regular Exercise on Adult Asthma

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ClinicalTrials.gov Identifier: NCT02012400
Recruitment Status : Completed
First Posted : December 16, 2013
Last Update Posted : May 11, 2017
Information provided by (Responsible Party):

Study Description
Brief Summary:
The purpose of this study is to assess the effects of regular exercise on physical fitness, asthma control, and quality of life among adult asthmatics.

Condition or disease Intervention/treatment
Asthma Other: Exercise

Study Design

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 131 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Effects of Regular Exercise on Physical Fitness, Asthma Control and Quality of Life of Adult Asthmatics
Study Start Date : August 2011
Primary Completion Date : June 30, 2015
Study Completion Date : June 30, 2015

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arms and Interventions

Arm Intervention/treatment
Experimental: Intervention group Other: Exercise
The exercise group is given a 24-week individualized training program, including aerobic exercise, muscular training, relaxation exercises and stretching. Patients are asked to observe their asthma control daily and to mark in their diary asthma symptoms and activity limitations as well as duration, intensity and form of exercising on daily basis. They are also asked to perform PEF-measurements twice a day for one-week period every 4 weeks. The control group receives ordinary instructions.
No Intervention: Control group

Outcome Measures

Primary Outcome Measures :
  1. Asthma control [ Time Frame: 6-month period ]
    Asthma control based on symptom score and PEF-values

Secondary Outcome Measures :
  1. Physical fitness [ Time Frame: Baseline and 6 months ]
    Physical fitness measured with spiroergometry

Other Outcome Measures:
  1. Lung function [ Time Frame: Baseline and 6 months ]
    Lung function measured with spirometry

  2. Quality of Life [ Time Frame: Baseline and 6 months ]
    Quality of life assessed using St. Georges Respiratory Questionnaire

  3. Step test [ Time Frame: Baseline and 6 months ]
    Indirect maximal oxygen consumption test using with 6 min step-walk-test

  4. Muscle strength and flexibility [ Time Frame: Baseline and 6 months ]
    Muscle strength and flexibility tests

Eligibility Criteria

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Ages Eligible for Study:   16 Years to 65 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • diagnosis of asthma made by physician, or reimbursement for asthma medication from the National Social Insurance Institution of Finland (code 203), or patient fulfills the diagnostic criteria for asthma as outlined in the Finnish Guidelines for Asthma Management (Käypä hoito -suositus 2006 and 2012)

Exclusion Criteria:

  • FEV1 < 60 % of predicted in spirometry
  • PEF variability > 30 % at least 2 times during a 1-week monitoring period
  • use of bronchodilating medication at least 4 times daily
  • permanent, daily steroid tablet treatment
  • patients who exercise regularly already at baseline at least 3 times a week at least 30 min at a time
  • serious coronary heart disease
  • severe hypotension
  • severe heart failure
  • severe musculoskeletal disorder
  • dementia
  • physician-diagnosed chronic obstructive lung disease
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02012400

Center for Environmental and Respiratory Health Research, University of Oulu
Oulu, Finland, 90014
Sponsors and Collaborators
University of Oulu
Foundation of the Finnish Anti-Tuberculosis Association
Research Foundation of the Pulmonary Diseases
Jalmari and Rauha Ahokas Foundation
Vaino and Laina Kivi Foundation
Ida Montin Foundation
Oulu University Hospital
More Information

Additional Information:
Responsible Party: University of Oulu
ClinicalTrials.gov Identifier: NCT02012400     History of Changes
Other Study ID Numbers: mjaakkola-001
First Posted: December 16, 2013    Key Record Dates
Last Update Posted: May 11, 2017
Last Verified: May 2017

Keywords provided by University of Oulu:
Asthma control
Physical fitness
Quality of life

Additional relevant MeSH terms:
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases