Bronchoreversibility and Radiologic Morphology of Emphysema
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|ClinicalTrials.gov Identifier: NCT02008162|
Recruitment Status : Unknown
Verified December 2013 by Eugenio Pompeo, University of Rome Tor Vergata.
Recruitment status was: Recruiting
First Posted : December 11, 2013
Last Update Posted : December 11, 2013
|Condition or disease||Intervention/treatment|
|Emphysema COPD||Drug: Bronchodilators|
|Study Type :||Observational|
|Estimated Enrollment :||60 participants|
|Official Title:||Response to Bronchodilation With Tiotropium Plus Salbutamol Correlates With Radiologic Morphology of the Lung in COPD of the Emphysematous Phenotype|
|Study Start Date :||November 2009|
|Actual Primary Completion Date :||December 2013|
Patients with severe heterogeneous emphysema selected as potential candidtes for lung volume reduction surgery.
Bronchodilators employed for the study include albuterol 200µg and tiotropium bromide 18 µg administered by puffs following a first spirometry and plethysmography performed after a washout period of 48h from all bronchodilators and subsequently repeated within 30 min after bronchodilators administration.
Administration of both albuterol and tiotropium bromide after a 48h period of washout from all bronchodilators, followed by spirometry and plethysmography
- post-bronchodilator FEV1 change [ Time Frame: 1 h ]Assessed by spirometry carried out before and after administration of bronchodilators
- post-bronchodilator change in FVC [ Time Frame: 1h ]Assessed by spirometry carried out before and after administration of bronchodilators
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02008162
|Fondazione Policlinico Tor Vergata||Recruiting|
|Rome, Italy, 00133|
|Contact: Eugenio Pompeo, MD +393496154524 email@example.com|
|Principal Investigator: Eugenio Pompeo, MD|
|Principal Investigator:||Eugenio Pompeo, MD||Tor Vergata University|