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The Influence of High Impact Exercise on Musculoskeletal Health in Older Men (Hiphop)

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ClinicalTrials.gov Identifier: NCT02007460
Recruitment Status : Completed
First Posted : December 10, 2013
Last Update Posted : December 10, 2013
Sponsor:
Collaborators:
University Hospitals Leicester NHS Trust, UK
University Hospitals of Derby and Burton NHS Foundation Trust
Information provided by (Responsible Party):
Katherine Brooke-Wavell, Loughborough University

Brief Summary:
Osteoporotic fractures are an extremely common and serious public health issue which contribute substantially to pain, impaired mobility and morbidity in the elderly. Declines in bone strength combined with an increase risk of falls (associated with decline in muscular function with age) are the main determinants of fracture risk. Exercise that is novel and involves impact loading has the potential to improve bone strength and neuromuscular function (strength, power and balance). It is thus imperative to evaluate potential benefits of exercise in older people. The musculoskeletal responses to exercise may also be influenced by vitamin D status. It is the purpose of this study to consider the influence of a one year unilateral (one limb) high impact exercise programme on musculoskeletal health, specifically bone structure, muscle strength and power in older caucasian men. It is also the purpose of this study to determine whether this differs according to vitamin D status. The findings will reveal whether exercise can improve bone health and/or neuromuscular function, and whether improvements are dependent upon vitamin D status.

Condition or disease Intervention/treatment Phase
Bone Strength Neuromuscular Function Behavioral: Exercise Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 50 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Basic Science
Official Title: The Influence of High Impact Exercise on Musculoskeletal Health in Older Men
Study Start Date : January 2010
Actual Primary Completion Date : January 2012
Actual Study Completion Date : January 2012

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Exercise leg Behavioral: Exercise
multidirectional unilateral hopping exercise

No Intervention: Control leg



Primary Outcome Measures :
  1. Change in femoral neck bone mineral density [ Time Frame: baseline, 12 months ]

Secondary Outcome Measures :
  1. Change in cortical bone mineral content [ Time Frame: baseline, 12 months ]
  2. Change in trabecular bone mineral content [ Time Frame: baseline, 12 months ]
  3. Change in ground reaction force during hopping [ Time Frame: baseline, 6 months, 12 months ]
  4. Change in electromyography of quadriceps during hopping [ Time Frame: baseline, 6 months ]
  5. Change in postural sway amplitude (mm) [ Time Frame: baseline, 6 months ]
  6. Change in leg press strength [ Time Frame: baseline, 6 months ]
  7. Change in maximal isometric knee extensor strength [ Time Frame: baseline, 6 months ]
  8. Change in tendon stiffness [ Time Frame: baseline, 6 months ]

Other Outcome Measures:
  1. Serum 25 hydroxy vitamin D [ Time Frame: baseline ]
  2. Change in body fat content [ Time Frame: baseline, 12 months ]
  3. change in energy intake (MJ/d) [ Time Frame: baseline, 12 months ]
  4. change in calcium intake [ Time Frame: baseline, 12 months ]


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Ages Eligible for Study:   65 Years to 80 Years   (Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy community dwelling men of white european origin

Exclusion Criteria:

  • BMI >30 kg/m2
  • History of strength training or recently ( previous 12 months) doing moderate physical activity (weight bearing, high impact)
  • Recent ( previous 12 months) or current medical or surgical problems likely to affect bone metabolism or provide contraindications to high impact exercise, balance or neuromuscular function
  • Any previous or existing lower back or limb problems that could be exacerbated by undertaking high impact exercise
  • Any history of diagnosed or symptomatic diseases likely to influence strength, power, bone or habitual activity (including osteomalacia or impaired liver/renal function and locomotor disease, hypertension) that influences bone or muscle or precludes exercise

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02007460


Locations
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United Kingdom
Loughborough University
Loughborough, Leicestershire, United Kingdom, LE11 3TU
Sponsors and Collaborators
Loughborough University
University Hospitals Leicester NHS Trust, UK
University Hospitals of Derby and Burton NHS Foundation Trust
Investigators
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Principal Investigator: Katherine Brooke-Wavell, PhD Loughborough University
Principal Investigator: Winston Rennie, MBBS University Hospitals Leicester NHS Trust
Principal Investigator: Jonathan Folland, PhD Loughborough University
Principal Investigator: Greg Summers, MD Derby University Hospitals Trust
Publications of Results:
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Responsible Party: Katherine Brooke-Wavell, Senior Lecturer in Human Biology, Loughborough University
ClinicalTrials.gov Identifier: NCT02007460    
Other Study ID Numbers: R10-P1
First Posted: December 10, 2013    Key Record Dates
Last Update Posted: December 10, 2013
Last Verified: December 2013