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The Role of Primary Motor Cortex and Prefrontal Cortex for Facilitation of Motor System and Working Memory

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ClinicalTrials.gov Identifier: NCT02006615
Recruitment Status : Unknown
Verified December 2013 by vghtpe user, Taipei Veterans General Hospital, Taiwan.
Recruitment status was:  Recruiting
First Posted : December 10, 2013
Last Update Posted : December 10, 2013
Sponsor:
Information provided by (Responsible Party):
vghtpe user, Taipei Veterans General Hospital, Taiwan

Brief Summary:
We hypothesize that ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.

Condition or disease Intervention/treatment Phase
Central Nervous System Diseases Device: rTMS Not Applicable

Detailed Description:
Excitatory (>3Hz) rTMS could facilitate the brain cortex and neuroplasticity that benefits motor control and working memory when the coil is applied over primary motor cortex or dorsolateral prefrontal gyrus.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 150 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Double (Participant, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: The Role of Primary Motor Cortex and Prefrontal Cortex for Facilitation of Motor System and Working Memory in Stroke, Parkinson, and Elderly Patients
Study Start Date : July 2013
Estimated Primary Completion Date : July 2015
Estimated Study Completion Date : July 2015

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: 5Hz rTMS
rTMS group
Device: rTMS
5Hz rTMS over M1 and inferior frontal lobe
Other Name: Magstim rapid2

Sham Comparator: Sham rTMS
Sham stimulation
Device: rTMS
5Hz rTMS over M1 and inferior frontal lobe
Other Name: Magstim rapid2




Primary Outcome Measures :
  1. Repeatable Battery for the Assessment of Neuropsychological Status [ Time Frame: up to 3 months ]

Secondary Outcome Measures :
  1. Reaction time [ Time Frame: up to 3 months ]


Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Ischemic or hemorrhagic cerebrovascular lesion, Parkinsonism disease, elderly people

Exclusion Criteria:

  • Seizure, metalic implantation, other contra-indications for TMS; Dementia or severe cognitive impairment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02006615


Contacts
Contact: Po-Yi Tsai, MD 886-228757293 vivitsai0518@gmail.com
Contact: Chih-Jou Lai, MD 886-228757361 milly1204@gmail.com

Locations
Taiwan
Taipei Veterans General Hospital Recruiting
Taipei, Taiwan, 11217
Contact: Po-Yi Tsai, MD    886-228757293    vivitsai0518@gmail.com   
Sponsors and Collaborators
Taipei Veterans General Hospital, Taiwan
Investigators
Principal Investigator: Po-Yi Tsai, MD Taipei Veterans General Hospital, Taiwan

Additional Information:
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: vghtpe user, MD, Taipei Veterans General Hospital, Taiwan
ClinicalTrials.gov Identifier: NCT02006615     History of Changes
Other Study ID Numbers: 2013-07-011A
First Posted: December 10, 2013    Key Record Dates
Last Update Posted: December 10, 2013
Last Verified: December 2013

Additional relevant MeSH terms:
Nervous System Diseases
Central Nervous System Diseases