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Epigenetic Influences on Post-Surgical Acute and Chronic Pain

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ClinicalTrials.gov Identifier: NCT02002520
Recruitment Status : Unknown
Verified January 2014 by Cheung Chi Wai, The University of Hong Kong.
Recruitment status was:  Recruiting
First Posted : December 6, 2013
Last Update Posted : January 22, 2014
Sponsor:
Information provided by (Responsible Party):
Cheung Chi Wai, The University of Hong Kong

Brief Summary:

Pain is the way our brain interprets certain bodily sensations. It is very difficult to describe or to put into words as perception and tolerance of pain varies widely between individuals. It is known that age, gender and past experience and memory of past experience all contribute to patients' feelings of discomfort and tolerance of pain, but the reason why some patients actually do not experience any pain at all post surgery is still unknown.

Because pain affects every person at some point in their lives, it is of utmost importance that we can find more effective analgesic methods, and provide analgesia tailored to an individual's need as well as discovering new methods which may be able to identify those individuals who are more prone to suffering serious, or chronic pain. It has been proposed that epigenetic modifications may play a role in sensitivity to analgesia and response to trauma, such as post surgery. The effects of epigenetic changes on key genes and the role this plays in analgesia sensitivity and pain perception is deserving of further research.

Epigenetics is a growing field of study in which there are genetic modifications that do not involve changes to base sequences in a gene, but that result nonetheless in changes to gene expression. It has long been known that changes in gene expression play an important role in the establishment of pain states. But it is not known whether a priming injury can induce lasting epigenetic marks which would result in an increase in both postoperative acute pain and the risk for chronic pain. Only by fully understanding these epigenetic mechanisms will we be able to offer better drugs for the treatment of pain, and to identify those at high risk of postoperative pain and postsurgical chronic pain.

The purpose of this study is to determine whether severity of pain following surgical procedures, such as third molar surgery is related to baseline methylation status of the promoter region of IL-6 and TNF-α and changes in methylation status post surgery.


Condition or disease
Acute Pain

  Show Detailed Description

Study Type : Observational
Estimated Enrollment : 120 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: An Exploratory Study of the Epigenetic Influences on Post-Surgical Acute and Chronic Pain
Study Start Date : January 2014
Estimated Primary Completion Date : September 2014
Estimated Study Completion Date : November 2014

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Chronic Pain

Group/Cohort
case group
patients undergo third molar surgery
control group
subjects do not require surgery



Primary Outcome Measures :
  1. pain score [ Time Frame: From postoperative 1 hour to postoperative 3 months ]

Secondary Outcome Measures :
  1. IL-6 and TNF-α expression [ Time Frame: From postoperative 1 hr to postoperative 3 month ]

Biospecimen Retention:   Samples With DNA
RNA and DNA


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Subjects at Prince Philip Dental Hospital and Queen Mary Hospital
Criteria

Inclusion Criteria:

  • Patient requires third molar surgery for case group and patient does not require surgery for control group
  • Age 18 or above
  • Ability to read and understand the study information and consent form
  • Written consent obtained

Exclusion Criteria:

  • Patient does not requires third molar surgery for case group and patient requires third molar surgery for control group
  • Age below 18
  • Major cognitive or psychiatric disorders that affect the ability to complete study
  • Refuse to participate

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02002520


Contacts
Contact: Chi W Cheung 852 22553303 cheuncw@hku.hk

Locations
Hong Kong
Department of Anaesthesiology, The University of Hong Kong Recruiting
Hong Kong, Hong Kong, 0000
Contact: Yvonne Lee, MPhil    852-22553303    yves@hku.hk   
Department of Anaesthesiology, The University of Hong Kong Not yet recruiting
Hong Kong, Hong Kong, 0000
Contact: Chi W Cheung    852 22553303    cheucw@hku.hk   
Sponsors and Collaborators
The University of Hong Kong
Investigators
Principal Investigator: Chi W Cheung Department of Anaesthesiology, The University of Hong Kong

Responsible Party: Cheung Chi Wai, Associate Professor, The University of Hong Kong
ClinicalTrials.gov Identifier: NCT02002520     History of Changes
Other Study ID Numbers: UW13-354
First Posted: December 6, 2013    Key Record Dates
Last Update Posted: January 22, 2014
Last Verified: January 2014

Keywords provided by Cheung Chi Wai, The University of Hong Kong:
Acute pain
Epigenetic
Dental pain

Additional relevant MeSH terms:
Chronic Pain
Acute Pain
Pain
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms