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Memantine add-on for Cognitive and Negative Symptoms of Schizophrenia

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02001103
Recruitment Status : Unknown
Verified July 2016 by National Taiwan University Hospital.
Recruitment status was:  Recruiting
First Posted : December 4, 2013
Last Update Posted : July 12, 2016
Sponsor:
Information provided by (Responsible Party):
National Taiwan University Hospital

Brief Summary:

The specific aim of this project is to test if memantine add-on therapy will be helpful for patients with first episode schizophrenia who present with or without cognitive impairments and negative symptoms, to examine the efficacy and safety of memantine as an adjuvant agent to their ongoing maintenance therapy with atypical antipsychotics. Our objectives include:

  1. Test memantine add-on by 2 different dosages comparing to a placebo-controlled group of clinically stable first episode schizophrenic patients who are under second-generation antipsychotic maintenance therapy. The results will give us information regarding effective dosage and the profile of adverse drug reactions while using on this population.
  2. Examine whether the effect of memantine add-on will be affected by any significant baseline clinical variables or predisposed cognitive deficits. That is to say, if memantine will only demonstrate adjunctive effect on those who are cognitively impaired or its effect is independent from baseline cognitive functioning or the severity of baseline psychopathology.
  3. Examine the changes in negative symptoms as the secondary outcomes to see if such a cognitive enhancing effect to be concurrent with an improvement in negative symptoms or independent from changes in negative symptoms.
  4. Treat the changes in positive symptoms and other clinical outcomes, such as readmission, being employed/going back to school, and psycho-social functioning scores as the tertiary outcomes to examine the effectiveness of memantine add-on.

Condition or disease Intervention/treatment Phase
Schizophrenia Drug: Memantine Drug: Placebo Phase 3

Detailed Description:

Study design:

This is a 12-week double-blind randomized placebo-controlled trial of memantine add-on to concurrent antipsychotic therapy for clinically stable patients with first episode schizophrenia.

Study procedures:

Patients will be recruited from the outpatient clinic of the study hospital. We will hold information campaigns to encourage referrals once the clinical trial procedure is set. Patients will be assessed for eligibility based on the criteria detailed below. Written informed consent will be obtained from eligible subjects or the subjects' parents if they are younger than the age of 18 years. Baseline clinical and neuropsychological assessments will be done at first. Patients will receive a single dose of memantine 5 mg to test if any allergic reactions to those who have never used it before. And then they will be randomized into 3 groups: the first group receives a target dose of memantine 10 mg/day, the second group receives a target dose of memantine 20 mg/day, and the third is a placebo control group. Both the participants and the clinicians are blinded to the agents and dosage they are taking. The dose titrating schedule for medication groups will be 5 mg/day for the first week with an increment of 5 mg per week to reach their designated targeted dose. So the10 mg add-on group will reach their target dose by the beginning of the second week and the 20 mg/day add-on group will reach their target dose by the beginning of the fourth week. Participants will be scheduled to return visit on week 1, 2, 4, 8, and 12 for dispense of medication and clinical assessments. By the end of the 12-week trial, they will receive all clinical and neuropsychological assessments again.

To use the least resources and to make most use of the information, as well as take into account of attrition, we plan to recruit 40 patients for each group with a total of 120 participants.

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Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 120 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Memantine add-on for Improving Cognitive Impairments and Negative Symptoms in Patients With Schizophrenia
Study Start Date : January 2014
Estimated Primary Completion Date : July 2016
Estimated Study Completion Date : December 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Schizophrenia

Arm Intervention/treatment
Active Comparator: Memantine 10 mg/day
Dosing titration with 5 mg incremental each week Clinical follow-up/assessment at week 1, 2, 4, 8, and 12 Treatment duration: 12 weeks
Drug: Memantine

Pills of memantine, including 5 or 10 mg, all prepared in the same capsules as used in the placebo arm.

The Memantine 10 mg intervention arm will take 1 capsule of memantine and 1 capsule of placebo going into week 3.

Other Name: Ebixa

Drug: Placebo
Capsules with starch inside manufactured using the same capsules as used in the other 2 arms.

Active Comparator: Memantine 20 mg/day
Dosing titration with 5 mg incremental each week Clinical follow-up/assessment at week 1, 2, 4, 8, and 12 Treatment duration: 12 weeks
Drug: Memantine

Pills of memantine, including 5 or 10 mg, all prepared in the same capsules as used in the placebo arm.

The Memantine 10 mg intervention arm will take 1 capsule of memantine and 1 capsule of placebo going into week 3.

Other Name: Ebixa

Placebo Comparator: Placebo
Clinical follow-up/assessment at week 1, 2, 4, 8, and 12 Treatment duration: 12 weeks
Drug: Placebo
Capsules with starch inside manufactured using the same capsules as used in the other 2 arms.




Primary Outcome Measures :
  1. Change from baseline in neurocognitive function [ Time Frame: Baseline, Week 12 ]
    Continuous Performance Test (CPT), Wisconsin Card Sorting Test (WCST), Wechsler Adult Intelligence Scale-Third Edition (WAIS-III), Trail Making Tests, Mandarin version of Verbal Fluency Test and Wechsler Memory Scale-Third Edition (WMS-III).


Secondary Outcome Measures :
  1. Change from baseline in symptom severity during 12 weeks [ Time Frame: Baseline, Week 1, 2, 4, 8, 12 ]
    Mandarin version Positive and Negative Symptom Scale (PANSS) of Schizophrenia

  2. Change from baseline in adverse events during 12 weeks [ Time Frame: Baseline, Week 1, 2, 4, 8, 12 ]
    Udvalg for Kliniske Undersøgelser (UKU) Side Effect Rating Scale



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


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Ages Eligible for Study:   18 Years to 45 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Both male and female outpatients
  • Age 18-45 years old at the time of screening
  • A diagnosis of schizophrenia based on the Structured Clinical Interview for DSM-IV
  • Currently receiving treatment mainly by an atypical antipsychotic (risperidone, olanzapine, amisulpride, aripiprazole, quetiapine, ziprasidone, paliperidone), including long-acting injectable antipsychotic
  • A first generation antipsychotic agent only for a low-dose, as needed use purpose
  • No revised use of benzodiazepines, antidepressants, anticholinergics, or other concomitant medications during past 3 months

Exclusion Criteria:

  • A score of 5 or more on any of the 7 positive symptom items of the PANSS rating at screening
  • Scores of 4 on at least 3 of the 7 positive symptom items of the PANSS rating at screening
  • Currently under clozapine treatment
  • A change of current antipsychotic medication in recent 3 months
  • Mental retardation known as IQ below 70 prior to the diagnosis of schizophrenia
  • A history of pervasive mental disorder or bipolar disorder
  • A medical condition with significant cognitive sequelae
  • A history of substance dependence
  • A history of hypersensitivity to memantine or other drugs of the same class, such as amantadine
  • Pregnancy, plan to get pregnant during the study period, or lactating women
  • Abnormal liver function (AST, ALT higher than doubling the upper limits of normal range) or abnormal renal function (blood creatinine > 1.3 mg/dL)
  • A history of epilepsy
  • A history of myocardial infarction, congestive heart failure, uncontrolled hypertension, stroke, or severe heart block.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02001103


Contacts
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Contact: Chen-Chung Liu, MD, PhD 886-2-23123456 ext 66130 chchliu@ntu.edu.tw

Locations
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Taiwan
National Taiwan University Hospital Recruiting
Taipei, Taiwan
Contact: Chen-Chung Liu, MD,PhD    +886-2-23123456 ext 66130    chchliu@ntu.edu.tw   
Sub-Investigator: Yi-Ting Lin, MD PhD         
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
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Principal Investigator: Chen-Chung Liu, MD, PhD National Taiwan University Hospital
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Responsible Party: National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT02001103    
Other Study ID Numbers: 201112171MID
First Posted: December 4, 2013    Key Record Dates
Last Update Posted: July 12, 2016
Last Verified: July 2016
Keywords provided by National Taiwan University Hospital:
adjuvant therapy
cognitive deficits
first episode schizophrenia
glutamate hypothesis
memantine
negative symptoms
Additional relevant MeSH terms:
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Schizophrenia
Schizophrenia Spectrum and Other Psychotic Disorders
Mental Disorders
Memantine
Antiparkinson Agents
Anti-Dyskinesia Agents
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Excitatory Amino Acid Antagonists
Excitatory Amino Acid Agents