Succinylcholine vs Rocuronium for Prehospital Emergency Intubation (CURASMUR)
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|ClinicalTrials.gov Identifier: NCT02000674|
Recruitment Status : Completed
First Posted : December 4, 2013
Last Update Posted : December 15, 2017
|Condition or disease||Intervention/treatment||Phase|
|Coma Major Trauma Respiratory Distress Shock||Drug: Succinylcholine : 1mg/kg Drug: Rocuronium : 1.2 mg/kg||Phase 3|
All adult patients with spontaneous cardiac activity and requiring tracheal intubation in the pre hospital emergency context will be included. All intubation will be performed by an emergency physician or a nurse specialized in anesthesia. For patients with spontaneous cardiac activity, rapid sequence intubation will be performed to allow intubation.
Comparisons studied will be : Intubation success rate at the first laryngoscopy, glottis exposure assessed by Cormack and Lehane classification, difficult intubation rate assessed by the Intubation Difficult Score (IDS), the conditions of intubation assessed by the Copenhagen score, the need for alternative airway techniques and the immediate post intubation complications rate as vomiting, dental trauma, pulmonary inhalation, arterial desaturation , hypotension episodes and cardiac arrest occurrence.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||1321 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Succinylcholine vs Rocuronium for Prehospital Emergency Intubation : a Randomized Trial|
|Actual Study Start Date :||December 2013|
|Actual Primary Completion Date :||July 2016|
|Actual Study Completion Date :||July 2016|
Active Comparator: Administration of Succinylcholine
Intubation after IV administration of Succinylcholine 1mg/kg
Drug: Succinylcholine : 1mg/kg
Experimental: Administration of Rocuronium
Intubation after IV administration of Rocuronium 1.2 mg/kg
Drug: Rocuronium : 1.2 mg/kg
Other Name: ESMERON®
- First-pass intubation success rate [ Time Frame: between 1 hour to 3 hours after inclusion ]Measured by the proportion of successful intubation in the first laryngoscopy.
- Incidence of difficult intubation [ Time Frame: between 1 hour to 3 hours after inclusion ]measured by the Intubation Difficulty Scale
- Intubation conditions assessment [ Time Frame: between 1 hour to 3 hours after inclusion ]using the Copenhagen score
- Need for alternate airway devices [ Time Frame: between 1 hour to 3 hours after inclusion ]
- early intubation-related complications [ Time Frame: between 1 hour to 3 hours after inclusion ]complications : esophageal intubation, mainstem intubation, vomiting, pulmonary aspiration, dental trauma, bronchospasm or laryngospasm, ventricular tachycardia, arterial desaturation, hypotension, or cardiac arrest
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02000674
|Principal Investigator:||Xavier Combes, MD||CHU de La Réunion|