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Trial record 12 of 134 for:    "Sleep Deprivation"

The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT02000076
First Posted: December 3, 2013
Last Update Posted: May 16, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
Stockholm University
Information provided by (Responsible Party):
Mats Lekander, Karolinska Institutet
  Purpose
The main purpose of this study is to investigate the effects of partial sleep deprivation (PSD) on resting state brain connectivity, emotional contagion, empathy, and emotional regulation.

Condition Intervention
Sleep Deprivation Behavioral: Partial sleep deprivation allowing 3 h sleep at night Behavioral: Full sleep

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Investigator)
Primary Purpose: Basic Science
Official Title: The Stockholm Sleepy Brain Study: Effects of Sleep Deprivation on Cognitive and Emotional Processing in Young and Old

Further study details as provided by Mats Lekander, Karolinska Institutet:

Primary Outcome Measures:
  • Blood oxygen level-dependent response in amygdala to angry faces (t/z-score from statistical parametric mapping) [ Time Frame: Change between 1st and 2nd MRI scanning session (approx. 1 month later) ]
    This registration is made in order to pre-specify hypotheses in a basic science project. For a full list of outcomes and hypotheses, see study description (above).


Enrollment: 98
Study Start Date: November 2012
Study Completion Date: May 2014
Primary Completion Date: March 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Sleep deprivation
Partial sleep deprivation allowing 3 h sleep at night
Behavioral: Partial sleep deprivation allowing 3 h sleep at night
Participants sleep at home while monitored with ambulatory polysomnography. For the full sleep condition, they are instructed to go to bed and to get up at the usual times that they would normally do that. For the sleep deprivation condition, they are instructed to go to bed 3 hours before the time when they would usually get up, and then to get up at that time.
Other Names:
  • Sleep restriction
  • Sleep loss
Experimental: Full sleep
Sleep with no restriction
Behavioral: Full sleep
Participants sleep at home while monitored with ambulatory polysomnography. For the full sleep condition, they are instructed to go to bed and to get up at the usual times that they would normally do that. For the sleep deprivation condition, they are instructed to go to bed 3 hours before the time when they would usually get up, and then to get up at that time.

  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   20 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 20-30 years of age, inclusive OR 65-75 years of age, inclusive
  • Able to understand spoken and written Swedish (in order to understand instructions)
  • Normal or corrected-to-normal vision not using glasses
  • Not colour blind
  • Right-handed
  • Free from ferromagnetic objects in body
  • No history of any neurologic or psychiatric illness including drug abuse
  • No history of diabetes nor hypertension

    • No depression according to ratings using the Hospital Anxiety and Depression scale (HAD)
    • No insomnia according to ratings using the Insomnia Severity Index (ISI) and Karolinska Sleep Questionnaire (KSQ)
  • No use of psychotropic drugs
  • Not studying or working in medicine, psychology, nor behavioural science
  • Not suffering from severe seasonal allergy
  • No use of cortisone, anti-histamines, nor any other immune-modulating drugs
  • Habitual intake of no more than 4 cups of coffee per day or the equivalent in terms of caffeine
  • No daily use of nicotine

Exclusion Criteria:

  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02000076


Locations
Sweden
Karolinska Institutet, Karolinska Universitetssjukhuset i Solna
Stockholm, None/Not Applicable, Sweden, SE-17177
Sponsors and Collaborators
Mats Lekander
Stockholm University
Investigators
Study Chair: Torbjörn Åkerstedt, PhD Stockholm University
Principal Investigator: Mats Lekander, PhD Stockholm University, Karolinska Institutet
Principal Investigator: Håkan Fischer, PhD Stockholm University
  More Information

Additional Information:
Responsible Party: Mats Lekander, Professor, Karolinska Institutet
ClinicalTrials.gov Identifier: NCT02000076     History of Changes
Other Study ID Numbers: Sleepy Brain Study Wave 1
First Submitted: August 13, 2013
First Posted: December 3, 2013
Last Update Posted: May 16, 2016
Last Verified: May 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Plan Description: De-identified individual participant data will be shared through the openfmri.org data repository.

Keywords provided by Mats Lekander, Karolinska Institutet:
Sleep
resting state
functional connectivity
emotional contagion
empathy
emotional regulation

Additional relevant MeSH terms:
Sleep Deprivation
Dyssomnias
Sleep Wake Disorders
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms
Mental Disorders