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Frequency of Dysphonia in Asthmatic Patients

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified November 2013 by University Hospital, Strasbourg, France.
Recruitment status was:  Not yet recruiting
Information provided by (Responsible Party):
University Hospital, Strasbourg, France Identifier:
First received: November 25, 2013
Last updated: December 3, 2013
Last verified: November 2013

For many years, it is known that asthmatics have more often dysphonia. However, no study has so far analyzed the reality of dysphonia in asthmatic by making phoniatric tests.

The etiology of dysphonia in asthmatic remains controversial. Indeed, for a long time, inhaled corticosteroids have been considered as responsible for organic abnormalities of the vocal cords. We hypothesized that women with asthma have more often dysphonia, and that dysphonia is rather functional origin.

Condition Intervention
Asthmatic Patients and Control Group
Other: Phoniatric tests

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Evaluation of the Frequency of Dysphonia by Subjective and Objective Methods in Asthmatic Patients

Further study details as provided by University Hospital, Strasbourg, France:

Primary Outcome Measures:
  • Evidence of dysphonia. The patient will be considered as having a dysphonia if at least one of the tests (Voice Handicap Index, Rank Rough Breathy Asthenic Strained GRBAS, Quotien Phonatoire QP and Fundamental laryngeal F0) is abnormal [ Time Frame: Four week ]

Estimated Enrollment: 180
Estimated Primary Completion Date: April 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: control group
  • the Phonatory Maximum Time
  • Vocal Handicap Index
  • Scale GRBAS of Hirano
  • Videolaryngoscopy
Other: Phoniatric tests
Other Names:
  • - the Phonatory Maximum Time
  • - Vocal Handicap Index
  • - Scale GRBAS of Hirano
  • - Videolaryngoscopy
Experimental: Asthmatic patients
  • The Phonatory Maximum Time
  • Vocal Handicap Index
  • Scale GRBAS of Hirano
  • Videolaryngoscopy
Other: Phoniatric tests
Other Names:
  • - the Phonatory Maximum Time
  • - Vocal Handicap Index
  • - Scale GRBAS of Hirano
  • - Videolaryngoscopy


Ages Eligible for Study:   18 Years to 65 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Women
  • Aged between 18 to 65 years
  • Patient who signed the informed consent.
  • affiliated with a social security system.

Patients with asthma (GINA criteria)

- persistent asthma with inhaled corticosteroids.

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Please refer to this study by its identifier: NCT01999855

Contact: Frédéric De Blay

Service de pneumologie, d'allergologie et de pathologie de l'environnement Not yet recruiting
Strasbourg, France, 67091
Contact: Frédéric De Blay, Pr   
Sub-Investigator: Philippe SCHULTZ, Md PhD         
Sub-Investigator: Cindy Barnig, MD         
Sub-Investigator: Elisabeth PERI, MD         
Sponsors and Collaborators
University Hospital, Strasbourg, France
Principal Investigator: Frédéric De Blay, Pr Pôle de Pathologie Thoracique- Hôpitaux Universitaires Strasbourg
  More Information

Responsible Party: University Hospital, Strasbourg, France Identifier: NCT01999855     History of Changes
Other Study ID Numbers: 5517
Study First Received: November 25, 2013
Last Updated: December 3, 2013

Additional relevant MeSH terms:
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Immune System Diseases
Voice Disorders
Laryngeal Diseases
Otorhinolaryngologic Diseases
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms processed this record on May 25, 2017