NEAT - Prevention and Treatment of Overweight and Obesity. (InphactUm)

• ClinicalTrials.gov Identifier: NCT01997970
• Recruitment Status: Completed
• First Posted: November 28, 2013
• Last Update Posted: May 12, 2016
• Sponsor: Umeå University
• Information provided by (Responsible Party): Tommy Olsson, Umeå University

Study Description

Brief Summary:

This study will investigate the effect on Non-exercise Activity Thermogenesis (NEAT) when implementing active workstation at offices compared to conventional office work. The primary hypothesis is that this implementation will lead to a significant increase in time spent walking per day.

Condition or disease	Intervention/treatment	Phase
Overweight; Obesity	Behavioral: Treadmill workstation; Behavioral: Health talk	Not Applicable

Detailed Description:

NEAT consists of the energy expenditure of the physical activities that are non sporting-like and that we perform in our everyday life, such as walking, cleaning, shoveling snow etc. Which occupation we have play a big role in how much we are able to active our NEAT during our days and those who have more active jobs can expend up to 1500kcal more per day than those with sedentary jobs.

This study aims to try and increase NEAT at offices where sedentary time often is high. Participants will be randomized to either an intervention group or to a control group. Participants in the control group will continue to work at their regular desk, but will receive an individual health talk in the beginning of the study where diet and physical activity recommendations will be discussed.Participants in the intervention group will receive the same individual health talk and a treadmill desk, which they will use for 12 months at self-selected speed. They will be recommended to walk on the treadmill for at least 1 hour per day.

Study Design

• Study Type: Interventional (Clinical Trial)
• Actual Enrollment: 80 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Single (Outcomes Assessor)
• Primary Purpose: Treatment
• Official Title: Non-exercise Activity Thermogenesis (NEAT) - Prevention and Treatment of Overweight and Obesity
• Study Start Date: February 2014
• Actual Primary Completion Date: December 2015
• Actual Study Completion Date: December 2015

Arms and Interventions

Arm	Intervention/treatment
Experimental: Treadmill workstation; Will receive a health talk with recommendations about diet and physical activity habits and will also receive a treadmill workstation at regular office site for 12 months.	Behavioral: Treadmill workstation; The intervention group will receive a treadmill workstation for 12 months. They will use this at self-selected speed and will be recommended to use this for at least 1 hour per day. Participants in the control group will continue with conventional office work at their regular desk. Participants in the intervention group will receive four boosting e-mails during the study period, in which they will be encouraged to use the treadmill.; Behavioral: Health talk; Participants in both groups will receive a health talk with recommendations about diet and physical activity habits.
Experimental: Control group; Will receive a health talk with recommendations about diet and physical activity habits. Will continue to work with conventional office work at their regular desk.	Behavioral: Health talk; Participants in both groups will receive a health talk with recommendations about diet and physical activity habits.

Outcome Measures

Primary Outcome Measures :

1. Change from baseline in physical activity and sedentariness at 12 months [ Time Frame: Baseline, 12 months ]
   Measured with an accelerometer (ActiGraph) and an inclinometer (ActivPAL).

Secondary Outcome Measures :

1. Change from baseline in metabolism at 12 months [ Time Frame: Baseline, 12 months ]
   Metabolism: 2h glucose tolerance test. lipids, Hb1Ac
2. Change from baseline in anthropometrics at 12 months [ Time Frame: Baseline, 12 months ]
   Length, height, weight, waist circumference, hip circumference, sagittal height, pulse, blood pressure.
3. Change from baseline in body composition at 12 months [ Time Frame: Baseline, 12 months ]
   Measured with Dual X-Ray Absorptiometry (DXA)
4. Change from baseline in musculoskeletal pain at 12 months [ Time Frame: Baseline, 12 months ]
   Measured with the Chronic Pain Grade Questionnaire
5. Change from baseline in stress at 12 months [ Time Frame: Baseline, 12 months ]
   Measured by assessing cortisol levels in the saliva at 4 time points during one day. Also measured with the stress- and energy scale.
6. Change from baseline in depression/anxiety at 12 months [ Time Frame: Baseline, 12 months ]
   Measured with the Hospital Anxiety and Depression Scale.
7. Change from baseline in Quality of Life at 12 months [ Time Frame: Baseline, 12 months ]
   Measured with 2 questions from the SF-36.
8. Change from baseline in cognitive Function and functional brain response at 12 months [ Time Frame: Baseline, 12 months ]
   Measured with a cognitive test battery and functional MRI (fMRI). Levels of Brain-Derived Neurotrophic Factor (BDNF) is measured in the plasma.
9. Qualitative interview study [ Time Frame: 12 months ]
   Participants will be interviewed about experiences from being part of the study and about attitudes and factors that influences them to be physically active.

Eligibility Criteria

• Ages Eligible for Study: 40 Years to 67 Years (Adult, Older Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Criteria

Inclusion Criteria:

• Office workers with mainly sedentary tasks
• BMI 25-40

Exclusion Criteria:

• Severe depression and/or anxiety
• Exhaustion disorder
• Diabetes Mellitus
• Severe cardiovascular disease
• Severe kidney disease
• Musculoskeletal disorders that prohibit walking on a treadmill
• Contraindications for physical activity
• Thyroidea illness
• Pregnancy

For fMRI-study, additional exclusion criteria are:

• Implanted metal- or electrical devices
• Pregnancy
• Extraneous metal pieces in the body

Contacts and Locations

Locations

Sweden

Umeå University

Umeå, Sweden

Sponsors and Collaborators

Umeå University

Investigators

• Principal Investigator: Tommy Olsson, Professor; Umeå University

More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):

Bergman F, Matsson-Frost T, Jonasson L, Chorell E, Sorlin A, Wennberg P, Ohberg F, Ryberg M, Levine JA, Olsson T, Boraxbekk CJ. Walking Time Is Associated With Hippocampal Volume in Overweight and Obese Office Workers. Front Hum Neurosci. 2020 Aug 20;14:307. doi: 10.3389/fnhum.2020.00307. eCollection 2020.

Bergman F, Wahlstrom V, Stomby A, Otten J, Lanthen E, Renklint R, Waling M, Sorlin A, Boraxbekk CJ, Wennberg P, Ohberg F, Levine JA, Olsson T. Treadmill workstations in office workers who are overweight or obese: a randomised controlled trial. Lancet Public Health. 2018 Nov;3(11):e523-e535. doi: 10.1016/S2468-2667(18)30163-4. Epub 2018 Oct 12.

Bergman F, Boraxbekk CJ, Wennberg P, Sorlin A, Olsson T. Increasing physical activity in office workers--the Inphact Treadmill study; a study protocol for a 13-month randomized controlled trial of treadmill workstations. BMC Public Health. 2015 Jul 10;15:632. doi: 10.1186/s12889-015-2017-6.

• Responsible Party: Tommy Olsson, Professor, Umeå University
• ClinicalTrials.gov Identifier: NCT01997970
• Other Study ID Numbers: 2013-338-31
• First Posted: November 28, 2013
• Last Update Posted: May 12, 2016
• Last Verified: May 2016

Keywords provided by Tommy Olsson, Umeå University:

NEAT; Treadmill desk

Additional relevant MeSH terms:

Obesity; Overweight; Overnutrition; Nutrition Disorders; Body Weight