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Trial record 19 of 158 for:    genetics AND Parkinson's disease

Genetic Polymorphism and Parkinson's Disease in Taiwanese

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ClinicalTrials.gov Identifier: NCT01996878
Recruitment Status : Completed
First Posted : November 27, 2013
Last Update Posted : November 27, 2013
Sponsor:
Information provided by (Responsible Party):
Shey-Lin Wu, Changhua Christian Hospital

Brief Summary:
To observe and analyze the correlation between Single Nucleotide polymorphisms (SNPs) and the incidence of Parkinson's disease in Taiwanese.

Condition or disease
Parkinson's Disease

Study Type : Observational
Actual Enrollment : 334 participants
Observational Model: Case Control
Time Perspective: Prospective
Official Title: Association Analysis of Single Nucleotide Polymorphisms and the Incidence of Parkinson's Disease in a Hospital-based Case-control Study in Taiwan
Study Start Date : February 2006
Actual Primary Completion Date : February 2007
Actual Study Completion Date : October 2013

Resource links provided by the National Library of Medicine


Group/Cohort
Case (Parkinson's disease patients)
Clinical diagnosis of Parkinson's disease (cases are diagnosed by the presence of at least three of the five following primary signs: rest tremor, bradykinesia, rigidity, impaired postural refluxes, and the presence of a sustained L-dopa response.)
Control (Healthy volunteers)
Healthy volunteers without Parkinson's disease



Primary Outcome Measures :
  1. single nucleotide polymorphisms in certain candidate genes [ Time Frame: 2 weeks ]

Biospecimen Retention:   Samples With DNA
Collect 10 mL peripheric blood for DNA extraction


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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Taiwanese
Criteria

Inclusion Criteria:

  • Clinical diagnosis of Parkinson's disease (case subjects are diagnosed by the presence of at least three of the five following primary signs: rest tremor, bradykinesia, rigidity, impaired postural refluxes, and the presence of a sustained L-dopa response.)
  • Healthy volunteers without Parkinson's disease

Exclusion Criteria:

  • Cases showing atypical features, including multiple system atrophy and progressive supranuclear gaze palsy, or secondary causes of Parkinsonism, such as neuroleptic drugs, infection, tumor, previous cerebrovascular accident and known toxins

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01996878


Locations
Taiwan
Department of Neurology, Chang-Hua Christian Hospital
Chang-Hua, Taiwan, 500
Sponsors and Collaborators
Changhua Christian Hospital
Investigators
Principal Investigator: Shey-Lin Wu, M.D. Chang Hua Christian Hospital

Responsible Party: Shey-Lin Wu, Superintedent, Changhua Christian Hospital
ClinicalTrials.gov Identifier: NCT01996878     History of Changes
Other Study ID Numbers: CCH060105
First Posted: November 27, 2013    Key Record Dates
Last Update Posted: November 27, 2013
Last Verified: November 2013

Keywords provided by Shey-Lin Wu, Changhua Christian Hospital:
Parkinson's disease
Genetic Polymorphism

Additional relevant MeSH terms:
Parkinson Disease
Parkinsonian Disorders
Basal Ganglia Diseases
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Movement Disorders
Neurodegenerative Diseases