Fatty Acid Taste Thresholds: Caproic, Lauric, Oleic, Linoleic, Linolenic
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|ClinicalTrials.gov Identifier: NCT01996566|
Recruitment Status : Completed
First Posted : November 27, 2013
Last Update Posted : October 15, 2015
|Condition or disease|
|Taste Sensitivity Fatty Acid Type|
|Study Type :||Observational|
|Estimated Enrollment :||30 participants|
|Official Title:||Fatty Acid Taste Thresholds: Caproic, Lauric, Oleic, Linoleic, Linolenic|
|Study Start Date :||January 2013|
|Actual Primary Completion Date :||August 2014|
|Actual Study Completion Date :||August 2015|
- Oral sensitivity to oleic, lauric, linoleic, linolenic and caproic acids measured by the ascending 3 alternative forced choice test as described in American Society and Testing and Methods E679 [ Time Frame: Measured at weekly intervals over 3 months ]Thresholds for taste of each fatty acid will be determined using the 3 alternative forced choice test. Participants will taste 3 samples, one of which contains a fatty acid, and select which sample they believe is different. The concentration of fatty acid used will range from very dilute to a maximum of 5%. The test is repeated over the range of concentrations until a participant is able to correctly identify the fatty acid or until the maximum concentration is reached.
- DNA sequence of potential fatty acid receptors (e.g., CD36, GPR120, GPR48) [ Time Frame: This will be collected at the final visit of the study, approximate 2-3 months from participant enrollment depending on how frequently the participant is able to come to the lab ]Saliva will be collected to analyze any correlations between fatty acid receptor genes and sensitivity.
- Amount of habitual dietary fat intake [ Time Frame: Baseline ]A survey will be administered to determine each participant's habitual dietary fat intake
- Measurement of hunger [ Time Frame: This will be measured at every study visit (21 visits plus 1 screening visit) over the 2-3 months of the study ]Participants will rate how hungry they are on a line scale because commencing each study threshold test
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01996566
|United States, Indiana|
|West Lafayette, Indiana, United States, 47907|