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Eastern Caribbean Health Outcomes Research Network (ECHORN) (ECHORN)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT01994811
Recruitment Status : Recruiting
First Posted : November 26, 2013
Last Update Posted : January 16, 2018
National Institute on Minority Health and Health Disparities (NIMHD)
Information provided by (Responsible Party):
Yale University

Brief Summary:
The Eastern Caribbean Health Outcomes Research Network (ECHORN) is a collaborative research study that examines the lifestyles, eating habits, and health behaviors associated with cancer, diabetes and heart disease in adult men and women living in the Eastern Caribbean.

Condition or disease
Cancer Cardiovascular Disease Diabetes

Detailed Description:
The Eastern Caribbean Health Outcomes Research Network (ECHORN) has two aims: (1) To form a research collaborative across the Eastern Caribbean islands of Puerto Rico, the U.S. Virgin Islands, Barbados, and Trinidad & Tobago to recruit and follow a community-dwelling adult cohort to estimate the prevalence of known and potential risk factors associated with the development of heart disease, cancer, and diabetes and (2) To enhance health outcomes research leadership capacity in the region through a series of dedicated activities locally and abroad. ECHORN will expand clinical research with racial/ethnic minority populations in a transitioning part of the globe now threatened with an epidemic of noncommunicable chronic diseases (NCD). ECHORN's findings will have direct implications for the health disparities research and policy agenda in the mainland United States. In the long term, the links ECHORN will facilitate with local health policy delegations and global strategic organizational partners will promote the translation of research to improve health outcomes across the region. The collection and storage of biological specimens will also contribute to national biomonitoring projects and has the potential to identify unique risk and protective factors in the development of NCD.

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Study Type : Observational
Estimated Enrollment : 4400 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Eastern Caribbean Health Outcomes Research Network (ECHORN)
Study Start Date : April 2013
Estimated Primary Completion Date : December 2018
Estimated Study Completion Date : December 2018

Primary Outcome Measures :
  1. Diabetes [ Time Frame: 2 years ]
    Development of diabetes

Secondary Outcome Measures :
  1. Cardiovascular disease [ Time Frame: 2 years ]
    Development of cardiovascular disease

Other Outcome Measures:
  1. Cancer [ Time Frame: 2 years ]
    Development of cancer

Biospecimen Retention:   Samples With DNA
Blood and Saliva samples

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
We plan to enroll and follow a community-based sample of the 4 ECHORN sites combined (total n = 4,400). We seek to populate the cohort to roughly approximate the populations of the participating sites and deliberately oversample from Barbados and the U.S.Virgin Islands(USVI) to maximize sample heterogeneity along race/ethnicity/culture. Puerto Rico residents will comprise 40% of the cohort (n=1760 total), Trinidad and Tobago residents at 30% (n=1320 total), Barbados residents at 20% (n =880) and the USVI at 10% (n=440).

Inclusion Criteria:

  • Greater than or equal to 18 years of age
  • English or Spanish language speaking
  • Resident of island at least 10 years
  • Able to provide informed consent
  • Non-institutionalized at the time of data collection
  • Stable contact/residential information
  • No plans to relocate from island within the next 5 years

Exclusion Criteria:

  • Pregnant at time of recruitment

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01994811

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Contact: Josefa L Martinez, Ph.D. 203-785-3532
Contact: Tara Rizzo, MPH

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University of the West Indies, Cave Hill Campus Recruiting
Bridgetown, Barbados, BB 11000
Contact: Peter O Adams, BSc. MBBS DM    246 417 4264      
Principal Investigator: Peter O Adams, BSc. MBBS DM         
Puerto Rico
University of Puerto Rico Medical Sciences Campus Recruiting
San Juan, Puerto Rico, 00936-5067
Contact: Cruz M Nazario, PhD    (787) 758-2525 ext 1-1429      
Principal Investigator: Cruz M Nazario, PhD         
Trinidad and Tobago
University of the West Indies, St. Augustine Campus Recruiting
St. Augustine, West Indies, Trinidad and Tobago
Contact: Rohan Maharaj, DM, MBBS    868 645 2018      
Principal Investigator: Rohan Maharaj, DM, MBBS         
Virgin Islands (U.S.)
University of the Virgin Islands Recruiting
Saint Thomas, Virgin Islands (U.S.), 00802-9990
Contact: Maxine Nunez, DPH, RN    340-693-1289      
Principal Investigator: Mazine Nunez, DPH, RN         
Sponsors and Collaborators
Yale University
National Institute on Minority Health and Health Disparities (NIMHD)
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Principal Investigator: Marcella Nunez-Smith, MD, MHS Yale School of Medicine

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Responsible Party: Yale University Identifier: NCT01994811     History of Changes
Other Study ID Numbers: 1108008959
5U24MD006938 ( U.S. NIH Grant/Contract )
First Posted: November 26, 2013    Key Record Dates
Last Update Posted: January 16, 2018
Last Verified: January 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Plan Description: A Data Access and Scientific Review Committee (DASR), was been established to oversee requests for research collaboration (e.g. ancillary studies, secondary data analyses, etc.) to ensure they are within the scope of ECHORN's research mandate. Per the ECHORN Data Access Policy, data from ECHORN's research studies will be available to only internal ECHORN researchers for up to 3 years post data collection completion. Following that period, de-identified, limited ECHORN datasets will be made available for public access.

Keywords provided by Yale University:
cardiovascular disease

Additional relevant MeSH terms:
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Cardiovascular Diseases