Study of Morphology and Functional Magnetic Resonance Imaging (MRI) Muscle Patients With Muscular Dystrophy Type FSHD Benefiting a Physical Training Introduced. (FSHD3)
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|ClinicalTrials.gov Identifier: NCT01990976|
Recruitment Status : Completed
First Posted : November 25, 2013
Last Update Posted : July 28, 2015
The safety of guided practice of physical activity in myopathies is increasingly accepted, including muscular dystrophies. In facioscapulohumeral dystrophy (FSHD), one of the most common muscular dystrophy, the aerobic training showed its physiological and functional efficiency without affecting the quality of life of patients. The issue of exercise therapy extended to all neuromuscular diseases, as has been rigorously analyzed, shows that the use of a training program combining endurance exercise targeted exercises and strength is even more relevant.
To complete the multidimensional assessments be managed by each team ( physiological assessments, functional tissue and quality of life) it is relevant to continue , for a descriptive study quantitative and qualitative analyzes by muscle imaging and spectroscopy (MRI and Nuclear Resonance Imaging (NMR) spectroscopy ).
|Condition or disease||Intervention/treatment|
|Muscular Dystrophy Facioscapulohumeral||Device: MRI Procedure: Biopsy|
|Study Type :||Observational|
|Actual Enrollment :||15 participants|
|Official Title:||Study of Morphology and Functional Magnetic Resonance Imaging (MRI) Muscle Patients With Muscular Dystrophy Type FSHD Benefiting a Physical Training Introduced.|
|Study Start Date :||May 2012|
|Actual Primary Completion Date :||June 2015|
|Actual Study Completion Date :||June 2015|
Only the patients who have participated to the FSHD1 study (NCT01116570) and the FSHD2 study (NCT01689480) can be included in this study.
In Paris centre, a total body NMR imaging will be done with standard T2- and T1-weighted images.
biopsy of the vastus lateralis muscle
- Parameters of MRI [ Time Frame: 30 months ]whole body imaging T1, T2-weighted
- Muscle tissue parameters [ Time Frame: 30 months ]muscle biopsy
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01990976
|CHU de Grenbole|
|Grenoble, France, 38000|
|CHU de Saint-Etienne|
|St Etienne, France, 42000|
|Principal Investigator:||Léonard FEASSON, MD-PhD||CHU de Saint-Etienne|