Pilot Study: Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators
This is a pilot study to finalize methods for a larger study being planned for the future. This research is being done to characterize performance of tasks, brain functioning, and the effects of psilocybin in individuals with a long-term meditation practice.
There are three different parts of the pilot study:
- Effects of psilocybin on psychological function: This version of the pilot study will involve 1 or 2 day-long psilocybin sessions, and several meetings and data assessment visits. You will make a total of about 5 to 10 visits to our research unit (the BPRU on the Johns Hopkins Bayview Campus).
- Performance on behavioral and cognitive tasks: This version of the pilot study will involve completing various behavioral and cognitive tasks at our research unit. You will make a total of about 1-10 visits to our research unit (the BPRU on the Johns Hopkins Bayview Campus).
- Brain functioning: This version of the study will involve 1 to 3 brain imaging (MRI) measurements. You will make a total of about 2 to 5 visits to our research unit (the BPRU on the Johns Hopkins Bayview Campus). The MRI measurements will be taken at the F.M. Kirby Research Center at the Kennedy Krieger Institute (across the street from the Johns Hopkins Hospital).
People who are between the ages of 25 and 80 years old, who have a current, regular meditation practice, and who meet the medical requirements may join.
Central Nervous System Agents
|Study Design:||Allocation: Non-Randomized
Endpoint Classification: Pharmacodynamics Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Pilot Study: Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators|
- Persisting Effects Questionnaire [ Time Frame: 8 weeks post session ] [ Designated as safety issue: No ]Measures changes in spirituality, personal well-being, relationships, and emotions.
- Hood Mysticism Scale [ Time Frame: End of session day ] [ Designated as safety issue: No ]Measures subjective experience associated with classical mystical experiences.
- States of Consciousness Questionnaire [ Time Frame: End of session day ] [ Designated as safety issue: No ]Measures subjective experience associated with classical mystical experiences.
|Study Start Date:||May 2013|
|Study Completion Date:||May 2014|
|Primary Completion Date:||January 2014 (Final data collection date for primary outcome measure)|
Experimental: Drug Only
psilocybin dose manipulation as described in the protocol
dose manipulation as described in the protocol
|No Intervention: Cognitive/Behavioral Tasks Only|
|No Intervention: Imaging Only|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01988311
|United States, Maryland|
|Behavioral Pharmacology Research Unit, Johns Hopkins Bayview Medical Center|
|Baltimore, Maryland, United States, 21224|
|Principal Investigator:||Roland R Griffiths, Ph.D.||Johns Hopkins University|