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Trial record 4 of 5 for:    "cowden syndrome"

French Digestive Polyposis Cohorte Family Adenomatous Polyposis With APC and MYH Gene Mutations , Cowden's Disease With PTEN Gene Mutation, Peutz Jeghers Disease With STK 11 Gene Mutation ,juvénil Polyposis With SMAD 4 Gene Mutation , Serrated and Hyperplastic Polyposis

This study is currently recruiting participants. (see Contacts and Locations)
Verified August 2016 by Hôpital Edouard Herriot
Information provided by (Responsible Party):
Jean Christophe Saurin, Hôpital Edouard Herriot Identifier:
First received: November 12, 2013
Last updated: August 29, 2016
Last verified: August 2016
French cohorte about polyposis digestive diseases

Condition Intervention
Quality of Life
Other: Procedure surgery behavioral and genetic diagnosis
Procedure: quality of life after different type of surgery

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: French Digestive Polyposis Cohorte

Resource links provided by NLM:

Further study details as provided by Hôpital Edouard Herriot:

Primary Outcome Measures:
  • genetic diagnosis or over 50 polyps in the stomach in the duodenum or in the colon [ Time Frame: 10 years ]

Biospecimen Retention:   Samples With DNA
Genetic Diagnostic

Estimated Enrollment: 350
Study Start Date: January 2011
Estimated Study Completion Date: August 2017
Primary Completion Date: August 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
digestive polyposis
Family adenomatous polyposis (APC or MYH genes) Peutz Jeghers Disease Cowden Disease Festooned Polyposis Juvenile Polyposis Hyperplastic Polyposis
Other: Procedure surgery behavioral and genetic diagnosis
Observational Study
Procedure: quality of life after different type of surgery

Detailed Description:
Family Adenomatous Polyposis APC and MYH Genes Peutz Jeghers Disease Cowden Disease Festooned polyposis Juvenile polyposis Hyperplastic polyposis

Ages Eligible for Study:   12 Years to 90 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Digestive Polyposis Cohort

Inclusion Criteria:

  • APC Gene mutation
  • MYH Homozygote mutation
  • COWDEN Disease with PTEN gene mutation
  • Peutz Jeghers Disease with STK 11 gene mutation
  • Juvenile polyposis with SMAD 4 gene mutation

Exclusion Criteria:

  • heterozygote MYH Gene Mutation
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01987518

Hopital Edouard Herriot Recruiting
Lyon, Rhone Alpes, France, 69000
Contact: Saurin Jean Christophe, msd    (33)0472117572   
Contact: Vinet Olivier, CRA    (33)0472110370   
Principal Investigator: jean christophe saurin, msd         
Sponsors and Collaborators
Hôpital Edouard Herriot
Principal Investigator: jean christophe saurin, msd HEH Hospital
  More Information

Responsible Party: Jean Christophe Saurin, Principal Investigator, Hôpital Edouard Herriot Identifier: NCT01987518     History of Changes
Other Study ID Numbers: Peps Data Base
SISRA ( Other Identifier: SISRA )
Study First Received: November 12, 2013
Last Updated: August 29, 2016 processed this record on May 25, 2017