Conversion From Total Intravenous Anesthesia Technique to Desflurane Anesthesia for Long Duration Neurosurgery
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|ClinicalTrials.gov Identifier: NCT01985854|
Recruitment Status : Unknown
Verified November 2013 by Makoto Ozaki, Tokyo Women's Medical University.
Recruitment status was: Not yet recruiting
First Posted : November 15, 2013
Last Update Posted : November 15, 2013
Since neurological testing during neurosurgery, such as somato-sensory evoked potentials, motor-evoked potentials, auditory evoked potentials and visual evoked potentials are well maintained their wave-form reactivity with total intravenous anaesthesia technique better than inhalational anesthetic techniques, the standard anesthesia method for neurosurgery is usually total intravenous anaesthesia technique. Nonetheless, after finishing recording the evoked potential responses during surgery, facilitation of recovery from general anesthesia is getting important, because the real neurological physical examination is much more sensitive than above electrical evoked potentials to evaluate the results of surgical operation.
We propose to evaluate the recovery parameters after conversion from total intravenous anaesthesia technique to Desflurane anesthesia during long term neurosurgery procedures. The conversion will be initiated upon completion of the neurophysiological electric evoked potentials assessment. Based on the pharmacological properties of desflurane, we hypothesize that recovery after conversion to Desflurane will be faster compared to recovery after total intravenous anaesthesia alone.
|Condition or disease||Intervention/treatment||Phase|
|Patients Undergoing Elective Craniotomy||Drug: Propofol Drug: Desflurane||Phase 4|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||60 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Conversion From Total Intravenous Anesthesia Technique to Desflurane Anesthesia for Long Duration Neurosurgery: A Pilot Study for Assessment of Recovery Parameters|
|Study Start Date :||January 2014|
|Estimated Primary Completion Date :||December 2016|
Active Comparator: Propofol
Propofol target-controlled infusion will be kept 2-4μg /ml plasma concentration throughout procedure.
Other Name: Diprivan
After taking off the electrophysiological monitoring from the patients, discontinue propofol and start desflurane from 6% (dialed concentration) at flow rate of 4L/min for 2 minutes in desflurane group. When achieve end tidal concentration of 4-5%, decrease the flow rate to 2L/min.
Other Name: Suprane
- Time from the discontinuation of anesthesia to extubation [ Time Frame: Patients will be followed in the operation room, an expected average of 30 minutes. ]
- Time from the discontinuation of anesthesia to eye opening [ Time Frame: At the end of surgery, duration time from the discontinuation of anesthesia to the eye opening will be measured, averaged expected time is 30 minutes ]
- Cognitive function [ Time Frame: Up to 24 hours ]Cognitive function will be measured by Mini-Mental state examination at baseline (preoperatively) 5 minutes and 24 hours after extubation. Postoperative recovery function will be also measured by Post-operative Quality Recovery Scale (PQRS scale) at 5 minutes and 24 hours after extubation.
- Time from the discontinuation of anesthesia to orientation [ Time Frame: Up to 24 hours ]Time from the discontinuation of anesthesia to orientation (State name, state the date of birth)
- Length of ICU stay [ Time Frame: Patients will be followed for the duration of intensive care unit stay, an expected average of 1 week ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01985854
|Contact: Makoto Ozaki, Ph.D||81-3-3353-8111 ext email@example.com|
|Tokyo Women's Medical University Hospital||Not yet recruiting|
|Tokyo, Japan, 1628666|
|Contact: Makoto Ozaki, Ph.D 81-3-3353-8111 ext 28290 firstname.lastname@example.org|
|Contact: Kasuya Yusuke, Ph.D 81-3-3353-8111 ext 29472 email@example.com|
|Principal Investigator: Makoto Ozaki, M.D, Ph.D|
|Sub-Investigator: Yusuke Kasuya, M.D, Ph.D|
|Sub-Investigator: Nobutada Morioka, M.D, Ph.D|
|Sub-Investigator: Shunichi Takagi, M.D, Ph.D|
|Sub-Investigator: Maho Kinoshita, M.D.|
|Sub-Investigator: Mirei Nagai, M.D, Ph.D|
|Sub-Investigator: Yoshikazu Okada, M.D, Ph.D|
|Study Chair:||Makoto Ozaki, Ph.D||Tokyo Women's Mecical University, Department of Anesthesiology|