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Memory Training Versus Yogic Meditation Training in Older Adults With Mild Cognitive Impairment

This study has been completed.
Information provided by (Responsible Party):
Helen Lavretsky, MD, University of California, Los Angeles Identifier:
First received: October 30, 2013
Last updated: June 28, 2016
Last verified: June 2016
The purpose of this pilot study is to test whether 6 months of supervised weekly Kundalini yoga classes and a brief daily meditation homework assignment can improve memory and thinking in older adults with mild memory complaints when compared to weekly classes of memory training with daily homework assignments.

Condition Intervention
Mild Cognitive Impairment
Behavioral: Kundalini yoga and meditation
Behavioral: Memory Training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Supportive Care
Official Title: Memory Training Versus Yogic Meditation Training in Older Adults With Mild Cognitive Impairment

Resource links provided by NLM:

Further study details as provided by University of California, Los Angeles:

Primary Outcome Measures:
  • Change in memory [ Time Frame: At baseline and at 6 months ]
    As measured by battery of neuropsychological tests

Secondary Outcome Measures:
  • Clinical Global Impression scale [ Time Frame: Baseline, weeks 2,4,6,8,10,12,24 ]
  • Geriatric Depression scale [ Time Frame: Baseline, weeks 2, 4, 6, 8, 10, 12, 24 ]
  • Change in fMRI connectivity [ Time Frame: 12 weeks ]
    FMRI scans will be obtained at baseline and after 12 weeks follow up

Estimated Enrollment: 66
Study Start Date: September 2013
Study Completion Date: May 2016
Primary Completion Date: May 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Memory Training
Group memory training will be administered for amnestic MCI
Behavioral: Memory Training
Participants will attend a weekly memory training class for 12 weeks as well as receive daily memory homework (12 minute duration) for the 12 weeks.
Experimental: Kundalini yoga and meditation
PArticipants will engage in weekly yoga classes and daily 20 minute meditation
Behavioral: Kundalini yoga and meditation
Participants will participate in a 60 minute yoga and meditation session weekly for 12 weeks and will be assigned a daily Kirtan kriya meditation (12 minute duration) for 12 weeks.

Detailed Description:

The purpose of this pilot study intervention is to investigate brain mechanisms of response to memory enhancement training (MET) compared to Kundalini yoga and Kirtan Kriya meditation using functional magnetic resonance imaging (fMRI) that will be acquired from each subject at baseline and at 12 weeks (post-randomization).

Overall, the investigators anticipate recruiting 66 adults with memory complaints and diagnosed with MCI for adults 55 years old and older. Subjects will either receive: (1) MET class for 60 minutes per week; or (2) Kundalini yoga and Kirtan Kriya meditation class for 60 minutes per week. All assessments will be completed immediately after the interventions for a total of 10 visits in 12 weeks and a follow-up visit at 6 months (24 weeks)to monitor the overall benefit of the intervention.


Ages Eligible for Study:   55 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Mild cognitive impairment amnestic type
  • Clinical Dementia Rating scale score of 0.5
  • SufficientEnglish proficiency and 8th grade or higher reading level as determined by the word reading subtest of the Wide Range Achievement Test-IV
  • Capacity to provide informed consent.

Exclusion criteria:

  • Any current or past psychiatric disorders, or recent unstable medical or neurological disorders
  • Any disabilities preventing their participation in the MET or HEW (e.g. severe visual or hearing impairment)
  • Insufficient English proficiency
  • Diagnosis of dementia
  • Mini Mental Health Examination score of 24 and below
  • Psychoactive medications
  • Participation in a psychotherapy that involves cognitive training
  • Do not meet criteria for Mild cognitive impairment subtype
  • Prior or current training in yoga.
  Contacts and Locations
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Please refer to this study by its identifier: NCT01983930

United States, California
UCLA Semel Institute
Los Angeles, California, United States, 90095
Sponsors and Collaborators
University of California, Los Angeles
Principal Investigator: Helen Lavretsky, MD, MS UCLA Semel Institute
  More Information

Responsible Party: Helen Lavretsky, MD, Professor, University of California, Los Angeles Identifier: NCT01983930     History of Changes
Other Study ID Numbers: 13-000821
Study First Received: October 30, 2013
Last Updated: June 28, 2016
Individual Participant Data  
Plan to Share IPD: No

Keywords provided by University of California, Los Angeles:
Memory impairment
memory training
Mild cognitive impairment

Additional relevant MeSH terms:
Cognition Disorders
Mild Cognitive Impairment
Neurocognitive Disorders
Mental Disorders processed this record on May 23, 2017