Memory Training Versus Yogic Meditation Training in Older Adults With Mild Cognitive Impairment
|Mild Cognitive Impairment||Behavioral: Kundalini yoga and meditation Behavioral: Memory Training|
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Supportive Care
|Official Title:||Memory Training Versus Yogic Meditation Training in Older Adults With Mild Cognitive Impairment|
- Change in memory [ Time Frame: At baseline and at 6 months ]As measured by battery of neuropsychological tests
- Clinical Global Impression scale [ Time Frame: Baseline, weeks 2,4,6,8,10,12,24 ]
- Geriatric Depression scale [ Time Frame: Baseline, weeks 2, 4, 6, 8, 10, 12, 24 ]
- Change in fMRI connectivity [ Time Frame: 12 weeks ]FMRI scans will be obtained at baseline and after 12 weeks follow up
|Study Start Date:||September 2013|
|Study Completion Date:||May 2016|
|Primary Completion Date:||May 2016 (Final data collection date for primary outcome measure)|
Active Comparator: Memory Training
Group memory training will be administered for amnestic MCI
Behavioral: Memory Training
Participants will attend a weekly memory training class for 12 weeks as well as receive daily memory homework (12 minute duration) for the 12 weeks.
Experimental: Kundalini yoga and meditation
PArticipants will engage in weekly yoga classes and daily 20 minute meditation
Behavioral: Kundalini yoga and meditation
Participants will participate in a 60 minute yoga and meditation session weekly for 12 weeks and will be assigned a daily Kirtan kriya meditation (12 minute duration) for 12 weeks.
The purpose of this pilot study intervention is to investigate brain mechanisms of response to memory enhancement training (MET) compared to Kundalini yoga and Kirtan Kriya meditation using functional magnetic resonance imaging (fMRI) that will be acquired from each subject at baseline and at 12 weeks (post-randomization).
Overall, the investigators anticipate recruiting 66 adults with memory complaints and diagnosed with MCI for adults 55 years old and older. Subjects will either receive: (1) MET class for 60 minutes per week; or (2) Kundalini yoga and Kirtan Kriya meditation class for 60 minutes per week. All assessments will be completed immediately after the interventions for a total of 10 visits in 12 weeks and a follow-up visit at 6 months (24 weeks)to monitor the overall benefit of the intervention.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01983930
|United States, California|
|UCLA Semel Institute|
|Los Angeles, California, United States, 90095|
|Principal Investigator:||Helen Lavretsky, MD, MS||UCLA Semel Institute|