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The Investigation of the Pre-movement Facilitation of Agonist-antagonist Muscles and the Effect of the Feedforward Rehabilitation in Individuals With Hypermetria

This study has been completed.
Information provided by (Responsible Party):
Ya-Ju Chang, Chang Gung University Identifier:
First received: November 7, 2013
Last updated: NA
Last verified: November 2013
History: No changes posted

In individuals with spino-cerebellar atrophy (SCA), the delayed onset of antagonist muscle firing has been reported to be the cause of hypermetria. Hypermetria is a common deficit in individuals with spino-cerebellar atrophy SCA when they perform ballistic goal-directed movement. Based on the previous studies, ballistic goal-directed movements are controlled by a triphasic pattern of agonistic and antagonistic muscle activation. The origin of the EMG pattern is a central program, whereas the delayed onset of antagonistic muscle firing has been reported to be the cause of hypermetria. To develop a therapy method, the difference in temporal pattern and intensity of supraspinal excitability of agonist and antagonist bursts between healthy adults and individuals with SCA when performing rapid and slow goal-directed movements should be further investigated.

Traditional rehabilitations of individuals with cerebellum lesion were limited to improve the functional performance of movement. Since the deficits of the goal-directed movement are at pre-movement programming, only feedforward training will be possible to re-establish an appropriate program.

Previous showed that peripheral stimulation resulted in a facilitation of motor cortex. Our group also found that this facilitation in individuals with SCA was similar to the ones without SCA. Therefore, it is possible to adjust the control pattern of supraspinal excitability of agonist and antagonist busts of SCA patient with passively providing electrical stimulation contains normal control pattern of healthy human.

The present study sought to investigate the difference in temporal pattern and intensity of supraspinal excitability of agonist and antagonist bursts between healthy adults and individuals with SCA when performing rapid and slow goal-directed movements.

Condition Intervention
Spinocerebellar Atrophy (SCA)
Other: Temporal electrical stimulation

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Ya-Ju Chang, Chang Gung University:

Primary Outcome Measures:
  • Muscle evoked potential(MEP) [ Time Frame: Baseline, 4 weeks. ]
    Measure of changes in MEP of flexor carpi radialis.

  • Electromyography(EMG) [ Time Frame: Baseline, 4 weeks ]
    Measure of changes in EMG of flexor carpi radialis and extensor carpi radialis.

  • Movement error [ Time Frame: Baseline, 4weeks ]
    Measure of changes in movement error during fast 30 degrees wrist extensions.

Enrollment: 40
Study Start Date: July 2009
Study Completion Date: June 2012
Primary Completion Date: June 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: health group 1
Health subjects received 30 mins delay antagonist activation temporal ES.
Other: Temporal electrical stimulation
Experimental: SCA group 1
SCA subjects received four weeks temporal ES assisted home training program.
Other: Temporal electrical stimulation
No Intervention: health group 2
health subjects controlled group
No Intervention: SCA group 2
SCA subjects controlled group


Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Clinical diagnosis of spinocerebellar ataxia
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Please refer to this study by its identifier: NCT01983670

Chang Gung University
Taoyuan, Taiwan, 333
Sponsors and Collaborators
Chang Gung University
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Ya-Ju Chang, Associate Professor, Chang Gung University Identifier: NCT01983670     History of Changes
Other Study ID Numbers: 98-0951B
Study First Received: November 7, 2013
Last Updated: November 7, 2013

Keywords provided by Ya-Ju Chang, Chang Gung University:
Pre-movement facilitation
Fast goal directed movement
Triphasic EMG pattern
Temporal electrical stimulation,
Spinocerebellar Ataxia

Additional relevant MeSH terms:
Spinocerebellar Ataxias
Spinocerebellar Degenerations
Cerebellar Ataxia
Cerebellar Diseases
Pathological Conditions, Anatomical
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Spinal Cord Diseases
Heredodegenerative Disorders, Nervous System
Neurodegenerative Diseases
Neurologic Manifestations
Genetic Diseases, Inborn processed this record on May 25, 2017