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The Effect of Whole Body Vibration Training on Neuromuscular Property in Individuals With Ataxia

This study has been completed.
Information provided by (Responsible Party):
Ya-Ju Chang, Chang Gung University Identifier:
First received: November 7, 2013
Last updated: November 13, 2013
Last verified: November 2013

The Cerebellum contains ten percent of the total volume of the brain and receives brain, spinal cord and vestibular sensory input. The organization of vestibular and somato-sensory afferent informations are also reported to be impaired in patients with cerebellum dysfunctions. Ataxia and impaired balance control are common symptoms in individuals with spinocerebellar ataxia (SCA). Previous studies have shown that patient with cerebellar damage are usually agonist and antagonist muscle coordination problem. Past studies also found the regulation of reciprocal Ia inhibition was impaired in patients with spinaocerebellar ataxia. In chronic phase, weakness might be developed due to deconditioned. All deficits mentioned above might lead to a decrease functional ability. Therefore, increasing somato-sensory and vestibular input, normalizing the modulation of recriprocal inhibition, and improve muscle strength might be able to improve the functional abilities of individuals with SCA.

Recently, whole body vibration (WBV) has been trained for health groups. Studies showed that WBV training were able to improve muscle strength, balance control, and functional ability. However, there is no evidence showed that whether the whole body vibration training can affect the brain and spinal cord for the regulation of neural circuits. Whether also can affect for maximal voluntary contraction and improve central fatigue. No previous studies that whole body vibration training for SCA.

Therefore, the purpose of this research was to investigate the intracortical facilitation and inhibition, reciprocal Ia inhibition, low frequency depression, maximal voluntary contraction, interpolated twitch technique to compare the different between the SCA and health subject. Also to investigate the short term and long term effect of WBV.

Condition Intervention
Spinocerebellar Ataxia Other: Whole body vibration training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Ya-Ju Chang, Chang Gung University:

Primary Outcome Measures:
  • Muscle twitch force [ Time Frame: Baseline, 4 weeks. ]
    Measure of changes in muscle twitch force by interpolation twitch technique

  • Muscle voluntary activity level [ Time Frame: Baseline, 4 weeks ]
    Measure of changes in muscle voluntary activity level by interpolation twitch technique.

  • Balance [ Time Frame: Baseline, 4 weeks ]
    Measure of changes in berge balance scale and one-leg standing.

  • Severity of cerebellar ataxia [ Time Frame: Baseline, 4 weeks ]
    Measure of changes in international cooperative ataxia rating scale(ICARS).

Enrollment: 17
Study Start Date: April 2011
Study Completion Date: March 2013
Primary Completion Date: March 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: WBV group
Stage 1: Short-term Whole body vibration(3 minutes in half-squatting position)
Other: Whole body vibration training
No Intervention: Non-WBV group
Stage 1 : Controlled group
Experimental: training group
Stage 2: Long-term WBV training (3 sessions per week for 4 weeks)
Other: Whole body vibration training
No Intervention: non-training group
Stage 2: Controlled group


Ages Eligible for Study:   20 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Clinical diagnosis of spinocerebellar ataxia
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Please refer to this study by its identifier: NCT01983631

Chang Gung University
Taoyuan, Taiwan, 333
Sponsors and Collaborators
Chang Gung University
  More Information

Responsible Party: Ya-Ju Chang, Associate Professor, Chang Gung University Identifier: NCT01983631     History of Changes
Other Study ID Numbers: 100-1184B
Study First Received: November 7, 2013
Last Updated: November 13, 2013

Keywords provided by Ya-Ju Chang, Chang Gung University:
Whole body vibration
Reciprocal inhibition
Spinocerebellar ataxia
voluntary activation level

Additional relevant MeSH terms:
Cerebellar Ataxia
Spinocerebellar Ataxias
Spinocerebellar Degenerations
Cerebellar Diseases
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Brain Diseases
Central Nervous System Diseases
Spinal Cord Diseases
Heredodegenerative Disorders, Nervous System
Neurodegenerative Diseases
Genetic Diseases, Inborn processed this record on September 21, 2017