The Effect of Whole Body Vibration Training on Neuromuscular Property in Individuals With Ataxia
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|ClinicalTrials.gov Identifier: NCT01983631|
Recruitment Status : Completed
First Posted : November 14, 2013
Last Update Posted : November 14, 2013
The Cerebellum contains ten percent of the total volume of the brain and receives brain, spinal cord and vestibular sensory input. The organization of vestibular and somato-sensory afferent informations are also reported to be impaired in patients with cerebellum dysfunctions. Ataxia and impaired balance control are common symptoms in individuals with spinocerebellar ataxia (SCA). Previous studies have shown that patient with cerebellar damage are usually agonist and antagonist muscle coordination problem. Past studies also found the regulation of reciprocal Ia inhibition was impaired in patients with spinaocerebellar ataxia. In chronic phase, weakness might be developed due to deconditioned. All deficits mentioned above might lead to a decrease functional ability. Therefore, increasing somato-sensory and vestibular input, normalizing the modulation of recriprocal inhibition, and improve muscle strength might be able to improve the functional abilities of individuals with SCA.
Recently, whole body vibration (WBV) has been trained for health groups. Studies showed that WBV training were able to improve muscle strength, balance control, and functional ability. However, there is no evidence showed that whether the whole body vibration training can affect the brain and spinal cord for the regulation of neural circuits. Whether also can affect for maximal voluntary contraction and improve central fatigue. No previous studies that whole body vibration training for SCA.
Therefore, the purpose of this research was to investigate the intracortical facilitation and inhibition, reciprocal Ia inhibition, low frequency depression, maximal voluntary contraction, interpolated twitch technique to compare the different between the SCA and health subject. Also to investigate the short term and long term effect of WBV.
|Condition or disease||Intervention/treatment||Phase|
|Spinocerebellar Ataxia||Other: Whole body vibration training||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||17 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Study Start Date :||April 2011|
|Actual Primary Completion Date :||March 2013|
|Actual Study Completion Date :||March 2013|
Experimental: WBV group
Stage 1: Short-term Whole body vibration(3 minutes in half-squatting position)
Other: Whole body vibration training
No Intervention: Non-WBV group
Stage 1 : Controlled group
Experimental: training group
Stage 2: Long-term WBV training (3 sessions per week for 4 weeks)
Other: Whole body vibration training
No Intervention: non-training group
Stage 2: Controlled group
- Muscle twitch force [ Time Frame: Baseline, 4 weeks. ]Measure of changes in muscle twitch force by interpolation twitch technique
- Muscle voluntary activity level [ Time Frame: Baseline, 4 weeks ]Measure of changes in muscle voluntary activity level by interpolation twitch technique.
- Balance [ Time Frame: Baseline, 4 weeks ]Measure of changes in berge balance scale and one-leg standing.
- Severity of cerebellar ataxia [ Time Frame: Baseline, 4 weeks ]Measure of changes in international cooperative ataxia rating scale(ICARS).
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01983631
|Chang Gung University|
|Taoyuan, Taiwan, 333|