Model-Based Image Reconstruction for X-Ray CT in Lung Imaging
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|ClinicalTrials.gov Identifier: NCT01979991|
Recruitment Status : Completed
First Posted : November 8, 2013
Last Update Posted : February 5, 2016
|Condition or disease||Intervention/treatment||Phase|
|Lung Diseases||Procedure: CT Imaging and Reconstruction||Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||184 participants|
|Intervention Model:||Single Group Assignment|
|Primary Purpose:||Basic Science|
|Official Title:||Model-Based Image Reconstruction for X-Ray CT in Lung Imaging|
|Study Start Date :||August 2010|
|Actual Primary Completion Date :||March 2015|
|Actual Study Completion Date :||December 2015|
Experimental: CT Imaging and Reconstruction
To develop a MBIR (model-based image reconstruction) method that will improve X-ray CT lung imaging by improving image quality and reducing dose.
Procedure: CT Imaging and Reconstruction
Patients will be consented for their permission to save and use the sinogram from their CT chest/lung scan. The sinogram will be de-identified and sent to an archive system for storage.
Later it will be exported to a computer for processing using MBIR (model based image reconstruction). The newly processed images will then be read by blinded readers. The quality of the images will be reviewed to determine if they are as readable and accurate as CT images created with the software that is currently being used.
- Developement of a computer program to improve CT image quality [ Time Frame: 6 years ]
Sinograms will be retrieved by an archive system and processed by MBIR (model-based image reconstruction) methods that we are developing that improve image quality (reduce noise, improve spatial resolution, reduce artifacts). We will evaluate the image quality both quantitatively and qualitatively.
We hope to develop and benchmark methods for algorithm acceleration to enable routine clinical use of MBIR (model-based image reconstruction) methods.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01979991
|United States, Michigan|
|University of Michigan Hospital|
|Ann Arbor, Michigan, United States, 48109|
|Principal Investigator:||Jeffrey Fessler, PhD||University of Michigan Hospital|
|Principal Investigator:||Jeffrey Fessler, PhD||University of Michigan|