Brain Mechanisms of Human Motivation
|ClinicalTrials.gov Identifier: NCT01976975|
Recruitment Status : Completed
First Posted : November 6, 2013
Last Update Posted : March 23, 2018
|Condition or disease|
|Major Depressive Disorder Bipolar Disorder|
|Study Type :||Observational|
|Actual Enrollment :||270 participants|
|Official Title:||Multi Level Analysis of Positive Valence Systems Across Mood Disorders|
|Study Start Date :||October 2013|
|Actual Primary Completion Date :||January 2018|
|Actual Study Completion Date :||January 2018|
Mood disorder patients
Patients with depressive and/or manic or hypomanic symptoms
Participants with no lifetime history of psychiatric illness
- Behavioral Performance in Probabilistic Reward Task [ Time Frame: Given once during the second session for a total of 10 minutes ]The probabilistic reward task is designed to measure sensitivity to reward and reward learning. It will be administered three times during session 1 to calculate changes in reward sensitivity.
- Behavioral Performance in Instrumental Learning Task [ Time Frame: Administered in session 3 during two hour long scan ]The instrumental learning task is designed to measure participant learning from reward and punishment.
- Symptom severity [ Time Frame: 6 months ]Participants will report on the phone about their symptom severity after completing all sessions.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01976975
|United States, Massachusetts|
|Belmont, Massachusetts, United States, 02478|
|Principal Investigator:||Diego A Pizzagalli, Ph.D.||Mclean Hospital|