The Effect of Age on the Hemodynamic Response During Rest and Exercise in Healthy Humans (HemReX)
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|ClinicalTrials.gov Identifier: NCT01974557|
Recruitment Status : Completed
First Posted : November 1, 2013
Last Update Posted : October 22, 2015
Primary: To observe how hemodynamic parameters are affected by age during rest and exercise in healthy humans. Furthermore, how an acute fluid challenge changes hemodynamic parameters.
Secondary: To thoroughly examine this population with regard to cardiac performance and function, anthropometrics, metabolic status, exercise capability, constitution, pulmonary status, and humoral markers of organ functions. This population will serve as a healthy control group, to which different populations can be compared, hence the need for a comprehensive characterization.
Diastolic function and parameters associated with diastolic function gradually deteriorate with increasing age. The gradual deterioration is unmasked at an earlier age during exercise and fluid challenge, compared to measurements made at rest.
|Condition or disease||Intervention/treatment||Phase|
|Hemodynamics||Other: Exercise||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||60 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Primary Purpose:||Basic Science|
|Official Title:||The Effect of Age on the Hemodynamic Response During Rest and Exercise in Healthy Humans|
|Study Start Date :||October 2013|
|Actual Primary Completion Date :||July 2015|
|Actual Study Completion Date :||July 2015|
- Composite of hemodynamic parameters [ Time Frame: minutes ]Invasive measurements using Swan-Ganz catheters and echocardiography will provide the data needed.
- Composite of humoral markers [ Time Frame: up to 1 hour ]Blood samples will be analysed with regard to humoral peptides and hormones that may affect hemodynamics.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01974557
|Dept. of Cardiology, Rigshospitalet, University Hospital of Denmark|
|Copenhagen, Denmark, 2100|
|Principal Investigator:||Finn Gustafsson, M.D. Msc||Chief Physician|