Sevoflurane Protective Effect on Ischemia Reperfusion Injury in Microvascular Surgery
This study aimed to evaluate the possible protective effect of anesthetic technique balanced (BAL) compared to total intravenous anesthetic technique (TIVA-TCI) in ischemia reperfusion injury in microvascular flap in plastic surgery. The investigators will evaluate the viability of the flap using tissue oximetry monitoring and the level of biochemical markers in a circle at the end of the intervention.
Microvascular Breast Flap in Plastic Surgery
Drug: Diprivan + Remifentanil TCI
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
- tissutal oximetry average value of the flap measured with INVOS (In Vivo Optical Spectroscopy) system continuously. [ Time Frame: 24 hours from the end of intervention ] [ Designated as safety issue: No ]
|Study Start Date:||January 2013|
|Estimated Primary Completion Date:||April 2015 (Final data collection date for primary outcome measure)|
Experimental: Bilanced group
Sevofluorane adjusted to obtain an Et-Sevo of 1.8-2%, for all the time of the surgical procedure.
Remifentanyl TCI adjusted according to protocol to maintain the range of 1-3 ng / ml.
Active Comparator: TCI group
Propofol 3-4 mg / ml and remifentanyl 1-3 ng / ml according to protocol TCI
|Drug: Diprivan + Remifentanil TCI|
Please refer to this study by its ClinicalTrials.gov identifier: NCT01972230
|Contact: federica firstname.lastname@example.org|
|Regina Elena Cancer Institute||Recruiting|
|Rome, RM, Italy, 00144|
|Contact: Forastiere Ester 00390652662994 email@example.com|
|Sub-Investigator: Claudia Claroni, MD|