Tissue Banking Study - Polycythemia Vera or Essential Thrombocythemia (PV & ET) Patients
|ClinicalTrials.gov Identifier: NCT01970930|
Recruitment Status : Completed
First Posted : October 28, 2013
Last Update Posted : January 19, 2018
|Condition or disease||Intervention/treatment|
|Polycythemia Vera Essential Thrombocythemia||Procedure: Blood specimen|
Specific Aim 1: Assess the effects of RG7112 on MPN HSC/HPC p53 levels and study how it affects MPN stem cell function.
Specific Aim 2. Assess the effects of a combination of low doses of IFNα and RG7112 on MPN HSC/HPC.
|Study Type :||Observational|
|Actual Enrollment :||131 participants|
|Official Title:||Treatment Strategies for Myeloproliferative Neoplasms by Targeting the Tumor Suppressor P53|
|Study Start Date :||August 2012|
|Primary Completion Date :||June 2, 2016|
|Study Completion Date :||June 2, 2016|
PV or ET
subject who has polycythemia vera or essential thrombocythemia
Procedure: Blood specimen
4 green top tube 40 cc of blood draw
- Stem cell function [ Time Frame: at one time study visit ]Assess the effects of RG7112 on MPN HSC/HPC p53 levels and study how it affects MPN stem cell function.
- CD34+ cells assays [ Time Frame: at one time study visit ]Assess the effects of a combination of low doses of IFNα and RG7112 on MPN HSC/HPC. After treatment with RG7112 and IFNα at the various doses, p53, MDM2, MDMX, phosphor-p38, and phosphor-STAT1 levels in MPN CD34+ cells will be measured using monoclonal antibody staining and flow cytometric and immunofluorescence analyses.
Biospecimen Retention: Samples Without DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01970930
|United States, New York|
|Icahn School of Medicine at Mount Sinai|
|New York, New York, United States, 10029|
|Principal Investigator:||Ronald Hoffman, MD||Icahn School of Medicine at Mount Sinai|