Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2015 by Helsinki University Central Hospital
Information provided by (Responsible Party):
Jouni Nurmi, Helsinki University Central Hospital Identifier:
First received: October 19, 2013
Last updated: March 17, 2015
Last verified: March 2015

The aim of the study is to describe the mechanisms of ultra-acute hyperglycemic response after return of spontaneous circulation (ROSC) in patients suffering out-of-hospital cardiac arrest. The investigators hypothesize that ischemia and reperfusion injury leads decreased secretion of insulin and glucose-like peptide 1 (GLP-1).

Two blood samples will be drawn: (1.) Immediately after ROSC and (2.) 60 minutes after first sample. Concentrations of glucose, insulin, glucagon and GLP-1 will be compared between the samples.

Metabolic profile will be compared between: (1.) diabetic and non-diabetic patients and (2.) survivors and non-survivors.

Heart Arrest
Cardiac Arrest

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Helsinki University Central Hospital:

Primary Outcome Measures:
  • Change in level of insulin [ Time Frame: 60 minutes ] [ Designated as safety issue: No ]
  • Change in level of glucagon [ Time Frame: 60 minutes ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Blood cortisol level [ Time Frame: 60 minutes after ROSC ] [ Designated as safety issue: No ]
  • Blood interleukin-6 level [ Time Frame: 60 minutes after ROSC ] [ Designated as safety issue: No ]
  • Change in blood glucose level [ Time Frame: 60 minutes ] [ Designated as safety issue: No ]
  • Change in level of GLP-1 [ Time Frame: 60 minutes ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

Estimated Enrollment: 40
Study Start Date: November 2013
Estimated Primary Completion Date: October 2015 (Final data collection date for primary outcome measure)

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Successfully resuscitated patients treated by physician staffed mobile intensive care unit in Helsinki area.

Inclusion Criteria:

  • age ≥18 years
  • witnessed cardiac arrest
  • interval form emergency call to return of spontaneous circulation 10-45 minutes

Exclusion Criteria:

  • severe pre-arrest disability leading to withdrawing treatment in prehospital phase
  • no concent from next of kin
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01968148

Contact: Jouni Nurmi, MD, PhD +358505951576

Helsinki Emergency Medical Services Recruiting
Helsinki, Finland
Contact: Ari Salo, MD    +35894711   
Helsinki Area Helicopter Emergency Medical Services Recruiting
Vantaa, Finland
Contact: Susanne Ångerman-Haasmaa, MD    +358 50 5818015   
Sponsors and Collaborators
Helsinki University Central Hospital
Principal Investigator: Jouni Nurmi, MD, PhD Helsinki University Central Hospital
  More Information

No publications provided

Responsible Party: Jouni Nurmi, MD, PhD, Helsinki University Central Hospital Identifier: NCT01968148     History of Changes
Other Study ID Numbers: 357/13/03/12/2012 § 205 
Study First Received: October 19, 2013
Last Updated: March 17, 2015
Health Authority: Finland: Ethics Committee

Keywords provided by Helsinki University Central Hospital:
cardiac arrest

Additional relevant MeSH terms:
Heart Arrest
Out-of-Hospital Cardiac Arrest
Cardiovascular Diseases
Heart Diseases processed this record on February 07, 2016