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Mechanisms of Ultra-acute Hyperglycemia After Successful Resuscitation From Out-of-hospital Cardiac Arrest

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ClinicalTrials.gov Identifier: NCT01968148
Recruitment Status : Unknown
Verified March 2015 by Jouni Nurmi, Helsinki University Central Hospital.
Recruitment status was:  Recruiting
First Posted : October 23, 2013
Last Update Posted : March 18, 2015
Information provided by (Responsible Party):

Study Description
Brief Summary:

The aim of the study is to describe the mechanisms of ultra-acute hyperglycemic response after return of spontaneous circulation (ROSC) in patients suffering out-of-hospital cardiac arrest. The investigators hypothesize that ischemia and reperfusion injury leads decreased secretion of insulin and glucose-like peptide 1 (GLP-1).

Two blood samples will be drawn: (1.) Immediately after ROSC and (2.) 60 minutes after first sample. Concentrations of glucose, insulin, glucagon and GLP-1 will be compared between the samples.

Metabolic profile will be compared between: (1.) diabetic and non-diabetic patients and (2.) survivors and non-survivors.

Condition or disease
Heart Arrest Cardiac Arrest

Study Design

Study Type : Observational
Estimated Enrollment : 40 participants
Observational Model: Cohort
Time Perspective: Prospective
Study Start Date : November 2013
Estimated Primary Completion Date : October 2015

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Groups and Cohorts

Outcome Measures

Primary Outcome Measures :
  1. Change in level of insulin [ Time Frame: 60 minutes ]
  2. Change in level of glucagon [ Time Frame: 60 minutes ]

Secondary Outcome Measures :
  1. Blood cortisol level [ Time Frame: 60 minutes after ROSC ]
  2. Blood interleukin-6 level [ Time Frame: 60 minutes after ROSC ]
  3. Change in blood glucose level [ Time Frame: 60 minutes ]
  4. Change in level of GLP-1 [ Time Frame: 60 minutes ]

Biospecimen Retention:   Samples Without DNA

Eligibility Criteria

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Successfully resuscitated patients treated by physician staffed mobile intensive care unit in Helsinki area.

Inclusion Criteria:

  • age ≥18 years
  • witnessed cardiac arrest
  • interval form emergency call to return of spontaneous circulation 10-45 minutes

Exclusion Criteria:

  • severe pre-arrest disability leading to withdrawing treatment in prehospital phase
  • no concent from next of kin
Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01968148

Contact: Jouni Nurmi, MD, PhD +358505951576 jouni.nurmi@helsinki.fi

Helsinki Emergency Medical Services Recruiting
Helsinki, Finland
Contact: Ari Salo, MD    +35894711    ari.salo@hus.fi   
Helsinki Area Helicopter Emergency Medical Services Recruiting
Vantaa, Finland
Contact: Susanne Ångerman-Haasmaa, MD    +358 50 5818015    susanne.angerman-haasmaa@hus.fi   
Sponsors and Collaborators
Helsinki University Central Hospital
Principal Investigator: Jouni Nurmi, MD, PhD Helsinki University Central Hospital
More Information

Responsible Party: Jouni Nurmi, MD, PhD, Helsinki University Central Hospital
ClinicalTrials.gov Identifier: NCT01968148     History of Changes
Other Study ID Numbers: 357/13/03/12/2012 § 205
First Posted: October 23, 2013    Key Record Dates
Last Update Posted: March 18, 2015
Last Verified: March 2015

Keywords provided by Jouni Nurmi, Helsinki University Central Hospital:
cardiac arrest

Additional relevant MeSH terms:
Heart Arrest
Out-of-Hospital Cardiac Arrest
Heart Diseases
Cardiovascular Diseases