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Synchronization to Improve Non-Adherence to Cardiovascular Medications (SyNCMed)

This study has been terminated.
CVS Caremark
Information provided by (Responsible Party):
Niteesh K. Choudhry, MD, PhD, Brigham and Women's Hospital Identifier:
First received: October 10, 2013
Last updated: January 7, 2016
Last verified: January 2016
The aim of this study is to evaluate if synchronizing when patients with diabetes and/or coronary artery disease fill their prescriptions improves long-term adherence to these medications.

Condition Intervention
Chronic Disease
Cardiovascular Disease
Diabetes Mellitus
Behavioral: Prescription synchronization

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Health Services Research
Official Title: Synchronization to Improve Non-Adherence to Cardiovascular Medications (SyNCMed)

Further study details as provided by Brigham and Women's Hospital:

Primary Outcome Measures:
  • Medication adherence [ Time Frame: 12 months ]
    Average adherence to medications for the treatment of cardiovascular disease and diabetes medications as assessed using administrative pharmacy claims

Secondary Outcome Measures:
  • Full adherence to medications for the treatment of diabetes or cardiovascular disease [ Time Frame: 12 months ]
    Percent of subjects achieving full adherence (defined as a Medication Possession Ratio > 80%) to medications for cardiovascular disease and diabetes

Other Outcome Measures:
  • Rates of de-synchronization [ Time Frame: 12 months ]
    Rate at which members whose prescriptions have been synchronized elect to discontinue with the synchronization during the study period

Enrollment: 3675
Study Start Date: November 2013
Study Completion Date: June 2014
Primary Completion Date: June 2014 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Prescription synchronization Behavioral: Prescription synchronization

Each patient's medication that has the greatest quantity of pills on hand after randomization will be defined as the "index "medication and partial supplies will be provided for all other eligible medications in order to synchronize all of a patient's medication. Prescribers will be contacted for a new prescription to ensure all eligible medications are on the same renewal schedule.

Randomization will occur within strata of whether patients are enrolled in the "ReadyFill@Mail" program. Once synchronized, patients who are not enrolled in the ReadyFill@Mail program will initiate their own refills. Patients who are enrolled in the ReadyFill@Mail program will have their refills automatically filled, however patients may disenroll from ReadyFill@Mail at any time, in which case they will initiate their own refills. Patients may disenroll in whole or in part from the program at any point.

No Intervention: Control


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
We will enroll patients 18 years of age and older who within 6 months of study enrollment have filled ≥ 2 medications intended for long-term use (i.e. maintenance medications) by mail order at CVS Caremark. At least 1 of these 2 medications of must be for the treatment of diabetes or cardiovascular disease. In addition, these medications must be delivered on two or more unique delivery dates, there must be at least one refill remaining for all eligible medications and either all or none of their prescriptions must be enrolled in the ReadyFill@Mail program (see Intervention Description for details).
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Please refer to this study by its identifier: NCT01963156

United States, Rhode Island
CVS Caremark
Woonsocket, Rhode Island, United States, 02895
Sponsors and Collaborators
Brigham and Women's Hospital
CVS Caremark
Principal Investigator: Niteesh K Choudhry, MD, PhD Brigham and Women's Hospital/Harvard Medical School
  More Information

Responsible Party: Niteesh K. Choudhry, MD, PhD, Associate Professor, Harvard Medical School, Brigham and Women's Hospital Identifier: NCT01963156     History of Changes
Other Study ID Numbers: Pro00008813
Study First Received: October 10, 2013
Last Updated: January 7, 2016

Keywords provided by Brigham and Women's Hospital:
Prescription synchronization
Cardiovascular disease
Medication adherence
Randomized controlled trial
Chronic disease
Pharmacy benefit design
Quality improvement

Additional relevant MeSH terms:
Diabetes Mellitus
Cardiovascular Diseases
Chronic Disease
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Disease Attributes
Pathologic Processes processed this record on May 24, 2017