Standardized Emergency Care for Community Acquired Pneumonia (CAP)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01963000
Recruitment Status : Completed
First Posted : October 16, 2013
Last Update Posted : October 16, 2013
Information provided by (Responsible Party):
Prof. Dr. Michael Christ, Klinikum Nürnberg

Brief Summary:

Community acquired pneumonia (CAP) is associated with a high in-hospital mortality. Standardization of diagnostics and adherence to sepsis bundles in the emergency department (ED) are associated with reduced mortality in patients with sepsis. Investigators examined whether the introduction of standardized care bundles and check lists in the ED are associated with a reduced mortality rate in patients hospitalized for CAP.

This is an observational trial. The investigators retrospectively analyzed performance indicators of 2819 consecutive patients with CAP admitted to the Nuremberg Hospital, Germany, from 2008 to 2009. At the turn of the year, implementation of CAP care bundles took place including interprofessional education, checklists and institutionalized feedback. Primary endpoint was in-hospital mortality of CAP patients. After the implementation of CAP care bundles in the ED, mortality of affected patients was significantly lower in 2009 compared to 2008. This study should demonstrate that the implementation of a standardized CAP care bundle in the ED is associated with a risk reduction in affected patients. Standardization of diagnostic and therapeutic processes in the ED therefore improves the outcome of patients hospitalized for CAP.

Condition or disease
Community Acquired Pneumonia Pneumonia Infection

Study Type : Observational
Actual Enrollment : 2819 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Reduction of Mortality in Community-Acquired Pneumonia After Implementing Standardized Care Bundles in the Emergency Department
Study Start Date : January 2007
Actual Primary Completion Date : December 2012
Actual Study Completion Date : December 2012

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Pneumonia

A patient with CAP was identified by encoding pneumonia without severe immunosuppression (HIV infection, solid organ or bone marrow/stem cell transplants, severe neutropenia) as the main diagnosis (ICD 10 GM) of hospital admission.

Primary Outcome Measures :
  1. mortality of CAP patients [ Time Frame: up to 14days ]

Secondary Outcome Measures :
  1. mortality up to 14days in subgroups [ Time Frame: up to 14 days ]

    Mortality of patients upt to 14day is determined in subgroups (different age groups, sub-groups of CRB-risk classes)

    CRB-65: C mental confusion; R respiratory rate ≥30/min; B systolic blood pressure <90 mm Hg; 65, age ≥65 years

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Emergency department patients

Inclusion Criteria:

  • all patients with community acquired pneumonia

Exclusion Criteria:

  • exacerbation of chronic obstructive pulmonary disease
  • malignancy
  • immunosuppression
  • neutropenia

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01963000

City Hospital Nuremberg
Nuremberg, Bavaria, Germany, 90419
Sponsors and Collaborators
Klinikum Nürnberg

Responsible Party: Prof. Dr. Michael Christ, Prof. Dr. med. Michael Christ, Klinikum Nürnberg Identifier: NCT01963000     History of Changes
Other Study ID Numbers: CAP01ED
First Posted: October 16, 2013    Key Record Dates
Last Update Posted: October 16, 2013
Last Verified: October 2013

Keywords provided by Prof. Dr. Michael Christ, Klinikum Nürnberg:
Community Acquired Pneumonia
Emergency Department
Standardized Care
Reduced Mortality
CRB-65 Risk Classes
Antibiotic Therapy

Additional relevant MeSH terms:
Disease Attributes
Pathologic Processes
Lung Diseases
Respiratory Tract Diseases
Respiratory Tract Infections