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Standardized Emergency Care for Community Acquired Pneumonia (CAP)

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01963000
First Posted: October 16, 2013
Last Update Posted: October 16, 2013
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Prof. Dr. Michael Christ, Klinikum Nürnberg
  Purpose

Community acquired pneumonia (CAP) is associated with a high in-hospital mortality. Standardization of diagnostics and adherence to sepsis bundles in the emergency department (ED) are associated with reduced mortality in patients with sepsis. Investigators examined whether the introduction of standardized care bundles and check lists in the ED are associated with a reduced mortality rate in patients hospitalized for CAP.

This is an observational trial. The investigators retrospectively analyzed performance indicators of 2819 consecutive patients with CAP admitted to the Nuremberg Hospital, Germany, from 2008 to 2009. At the turn of the year, implementation of CAP care bundles took place including interprofessional education, checklists and institutionalized feedback. Primary endpoint was in-hospital mortality of CAP patients. After the implementation of CAP care bundles in the ED, mortality of affected patients was significantly lower in 2009 compared to 2008. This study should demonstrate that the implementation of a standardized CAP care bundle in the ED is associated with a risk reduction in affected patients. Standardization of diagnostic and therapeutic processes in the ED therefore improves the outcome of patients hospitalized for CAP.


Condition
Community Acquired Pneumonia Pneumonia Infection

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Reduction of Mortality in Community-Acquired Pneumonia After Implementing Standardized Care Bundles in the Emergency Department

Resource links provided by NLM:


Further study details as provided by Prof. Dr. Michael Christ, Klinikum Nürnberg:

Primary Outcome Measures:
  • mortality of CAP patients [ Time Frame: up to 14days ]

Secondary Outcome Measures:
  • mortality up to 14days in subgroups [ Time Frame: up to 14 days ]

    Mortality of patients upt to 14day is determined in subgroups (different age groups, sub-groups of CRB-risk classes)

    CRB-65: C mental confusion; R respiratory rate ≥30/min; B systolic blood pressure <90 mm Hg; 65, age ≥65 years



Enrollment: 2819
Study Start Date: January 2007
Study Completion Date: December 2012
Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts
CAP
A patient with CAP was identified by encoding pneumonia without severe immunosuppression (HIV infection, solid organ or bone marrow/stem cell transplants, severe neutropenia) as the main diagnosis (ICD 10 GM) of hospital admission.

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Emergency department patients
Criteria

Inclusion Criteria:

  • all patients with community acquired pneumonia

Exclusion Criteria:

  • exacerbation of chronic obstructive pulmonary disease
  • malignancy
  • immunosuppression
  • neutropenia
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01963000


Locations
Germany
City Hospital Nuremberg
Nuremberg, Bavaria, Germany, 90419
Sponsors and Collaborators
Klinikum Nürnberg
  More Information

Responsible Party: Prof. Dr. Michael Christ, Prof. Dr. med. Michael Christ, Klinikum Nürnberg
ClinicalTrials.gov Identifier: NCT01963000     History of Changes
Other Study ID Numbers: CAP01ED
First Submitted: October 10, 2013
First Posted: October 16, 2013
Last Update Posted: October 16, 2013
Last Verified: October 2013

Keywords provided by Prof. Dr. Michael Christ, Klinikum Nürnberg:
Community Acquired Pneumonia
Emergency Department
Standardized Care
Reduced Mortality
CRB-65 Risk Classes
Antibiotic Therapy

Additional relevant MeSH terms:
Emergencies
Pneumonia
Disease Attributes
Pathologic Processes
Lung Diseases
Respiratory Tract Diseases
Respiratory Tract Infections