CMR in Patients With Myocarditis
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|ClinicalTrials.gov Identifier: NCT01962584|
Recruitment Status : Completed
First Posted : October 14, 2013
Last Update Posted : December 11, 2015
|Condition or disease|
|Suspected Acute Myocarditis|
Cardiac magnetic resonance (CMR) is an established non-invasive diagnostic tool for acute and chronic myocarditis. Established CMR criteria for diagnosing myocarditis are edema on black-blood T2-weighted imaging, relative contrast enhancement seen on T1-weighted imaging for assessment of hyperemia, and late contrast-agent enhancement seen with inversion recovery late enhancement technique for visualization of myocardial fibrosis.
Recently, tissue characterization based on calculation of myocardial T1 relaxation time (T1 mapping) as well as T1-derived extracellular volume fraction has become available. Recently, reference values for myocardial T1 relaxation times at 3T for healthy volunteers were published for CMR. However, to date no comprehensive data for multiparametric CMR in patients with suspected myocarditis at 3 Tesla is available. Therefore, the purpose of this prospective study was to evaluate the diagnostic value of CMR at 3T in patients with suspected acute myocarditis using a multiparametric CMR approach including T1 mapping as novel tool for tissue characterization.
CMR will be performed within 7 days after hospital admission for "suspected acute myocarditis".
|Study Type :||Observational|
|Actual Enrollment :||66 participants|
|Official Title:||Value of CMR Including T1 Mapping in Patients With Acute Myocarditis|
|Study Start Date :||September 2013|
|Actual Primary Completion Date :||October 2014|
|Actual Study Completion Date :||October 2014|
patients with suspected acute myocarditis
- T1 relaxation times [ Time Frame: time of CMR, CMR will be performed within 7 days after hospital admission for "suspected acute myocardtitis". ]quantification of T1 relaxation times
- Extracellular volume (ECV) [ Time Frame: time of CMR, CMR will be performed within 7 days after hospital admission for "suspected acute myocardtitis". ]calculation of extracellular volume based on T1 relaxation time
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01962584
|University of Bonn|
|Bonn, NRW, Germany, 53127|