ClinicalTrials.gov
ClinicalTrials.gov Menu

A Combined Training Program for Veterans With Amnestic Mild Cognitive Impairment

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT01962038
Recruitment Status : Completed
First Posted : October 14, 2013
Last Update Posted : April 5, 2018
Sponsor:
Collaborator:
U.S. Army Medical Research and Materiel Command
Information provided by (Responsible Party):
J. Kaci Fairchild, PhD, Palo Alto Veterans Institute for Research

Brief Summary:
The purpose of this study is examine the efficacy of a combination physical exercise and cognitive training program on improving memory in older Veterans with amnestic Mild Cognitive Impairment.

Condition or disease Intervention/treatment Phase
Amnestic Mild Cognitive Impairment Behavioral: Combined Aerobic and Resistance Exercise Behavioral: Stretching Exercises Behavioral: Cognitive Training Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 72 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: A Combined Training Program for Veterans With Amnestic Mild Cognitive Impairment
Study Start Date : May 2013
Actual Primary Completion Date : July 2017
Actual Study Completion Date : November 2017

Resource links provided by the National Library of Medicine

U.S. FDA Resources

Arm Intervention/treatment
Active Comparator: Combined Aerobic and Resistance Exercise/Cognitive Training Behavioral: Combined Aerobic and Resistance Exercise
Gym and home based aerobic and resistance exercises
Behavioral: Cognitive Training
Group-based cognitive training
Active Comparator: Stretching Exercises/Cognitive Training Behavioral: Stretching Exercises
Gym and home based stretching exercises
Behavioral: Cognitive Training
Group-based cognitive training



Primary Outcome Measures :
  1. Change from Baseline to 28 weeks in delayed recall of a word list [ Time Frame: Baseline, 24 weeks, 28 weeks ]
  2. Change from Baseline to 28 weeks in Delayed Recall of Names-Face Task [ Time Frame: Baseline, 24 weeks, 28 weeks ]

Secondary Outcome Measures :
  1. Non-Cognitive Outcomes (Depression, Sleep, Quality of Life) [ Time Frame: Baseline, Time 2, Time 3 ]

Other Outcome Measures:
  1. Exercise Assessment [ Time Frame: Baseline, Time 2, and Time 3 ]


Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   50 Years to 90 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • diagnosis of amnestic Mild Cognitive Impairment
  • available informant
  • visual and auditory acuity to allow neuropsychological testing
  • willingness to participate in exercise training + cognitive training for 8 months
  • approval of primary provider to participate in exercise trial

Exclusion Criteria:

  • current severe psychiatric disorder
  • diagnosis of dementia
  • history of neurological or system illness affecting CNS function
  • acute illness or unstable chronic illness
  • current severe cardiac disease
  • inability to exercise consistently because of orthopedic or musculoskeletal problems
  • morbid obesity
  • inability to read, verbalize understanding and voluntarily sign the informed consent

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01962038


Locations
United States, California
VA Palo Alto Health Care System
Palo Alto, California, United States, 94304
Sponsors and Collaborators
Palo Alto Veterans Institute for Research
U.S. Army Medical Research and Materiel Command
Investigators
Principal Investigator: Jennifer K Fairchild, PhD VA Palo Alto Health Care System

Responsible Party: J. Kaci Fairchild, PhD, Clinical Psychologist, Palo Alto Veterans Institute for Research
ClinicalTrials.gov Identifier: NCT01962038     History of Changes
Other Study ID Numbers: FAI0002AGG
First Posted: October 14, 2013    Key Record Dates
Last Update Posted: April 5, 2018
Last Verified: April 2018

Keywords provided by J. Kaci Fairchild, PhD, Palo Alto Veterans Institute for Research:
Mild Cognitive Impairment
Aging

Additional relevant MeSH terms:
Cognitive Dysfunction
Cognition Disorders
Neurocognitive Disorders
Mental Disorders