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Postprandial VLDL-TG Metabolism

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT01961024
First Posted: October 11, 2013
Last Update Posted: May 3, 2017
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
Esben Søndergaard, University of Aarhus
  Purpose
In thise study, we aim to determine the effect of meal fat on VLDL-TG kinetics in type 2 diabetic and healthy subjects matched for BMI in order to elucidate the potential pathophysiological differences in VLDL-TG FA channeling towards oxidation and storage in abdominal and leg subcutaneous adipose tissue. Specifically, we want to measure, by way of fat and muscle biopsies, the quantitative postprandial storage of VLDL-TG FA's in skeletal muscle and adipose tissue in relation to a series of tissue specific proteins and enzymes that might be involved in regulating skeletal muscle and adipose tissue FA storage.

Condition
Type 2 Diabetes

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Postprandial VLDL-TG Metabolism

Resource links provided by NLM:


Further study details as provided by Esben Søndergaard, University of Aarhus:

Primary Outcome Measures:
  • VLDL-TG storage in adipose tissue [ Time Frame: 3 hours ]

Secondary Outcome Measures:
  • 18F-THA fractional storage [ Time Frame: 6 Hours ]

Biospecimen Retention:   Samples With DNA
specimen of muscle specimen of adipose tissue

Enrollment: 21
Study Start Date: January 2014
Study Completion Date: August 2015
Primary Completion Date: August 2015 (Final data collection date for primary outcome measure)
Groups/Cohorts
Type 2 diabetic men
Age- and weight-matched controls

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years to 70 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Males with diabetes from the department´s out-patient clinic. Control group of healthy volunteers
Criteria

Inclusion Criteria:

  • Written consent

Exclusion Criteria:

  • Known diseases
  • Alcohol abuse
  • Smoker
  • Regular use of medicine
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01961024


Locations
Denmark
Department of Endocrinology MEA, Aarhus Hospital
Aarhus C, Please Select, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
  More Information

Responsible Party: Esben Søndergaard, Post Doc, MD, PhD, University of Aarhus
ClinicalTrials.gov Identifier: NCT01961024     History of Changes
Other Study ID Numbers: ES-0006
First Submitted: September 27, 2013
First Posted: October 11, 2013
Last Update Posted: May 3, 2017
Last Verified: May 2017

Keywords provided by Esben Søndergaard, University of Aarhus:
VLDL-TG kinetics
Postprandial state
Obesity