Music Therapy to Promote Emotion and Cognition for Dementia
Recruitment status was Recruiting
The purpose of this study is to determine if the effects of music therapy alter emotion and cognition performances of individuals with mild to moderate dementia. The music therapy intervention protocol is structured by drum improvisation, rhythm imitation, music cognition and song discussion. Attentive listening and active participation of the music training activities allow participants to utilize their focus of attention and comprehension of informational texts. Music therapy intervention is proposed to provide positive stimulations on emotion and cognitive functions of individuals with dementia. The results of the present study will clarify relationship between the effect of music therapy and the neural substrate of music therapy in anatomical and functional brain data obtained from MRI (fMRI).
|Study Design:||Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||The Effect of Music Therapy on Emotion and Cognition for Individuals With Mild to Moderate Dementia|
- Brain Changes from Baseline on Functional and Structural Connectivity at 2 Months by Multi-Model MRI Analyses [ Time Frame: Baseline and after 8-week music therapy intervention ] [ Designated as safety issue: Yes ]All participants will received two MRI scans at 0 and 2 months. Images will be acquired on a 3.0T Siemens MRI scanner with 12-channels head coil. All the images are acquired parallel to the anterior commissure-posterior commissure line. To minimize motion artifact generated during the image acquisition, each participant's head will be immobilized with cushions inside the coil. Three kinds of MRI techniques will be performed in this study, including T1-weighted high-resolution anatomical image, resting-state function MRI, and half-sphere diffusion spectrum imaging. Therefore, T1VBM(voxel-based morphology), TBSS(tract-based spatial statistics), functional brain network analysis, and structural brain network analysis will be employed for evaluating the changes of brain functional and structural connectivity in individuals with dementia in experimental and control groups.
- Change from Baseline on Geriatric Depression Scale (GDS) at 2 Months [ Time Frame: Baseline and at 2 Months ] [ Designated as safety issue: No ]
- Change from Baseline on Cohen-Mansfield Agitation Inventory (CMAI) at 2 Months [ Time Frame: Baseline and at 2 Months ] [ Designated as safety issue: No ]
- Change from Baseline on Inventory of Quality of Life (SF-36) at 2 Months [ Time Frame: Baseline and at 2 Months ] [ Designated as safety issue: No ]
- Change from Baseline on Frontal Assessment Battery (FAB) at 2 Months [ Time Frame: Baseline and at 2 Months ] [ Designated as safety issue: No ]
- Change from Baseline on Quality of Drum Improvisation at 2 Months [ Time Frame: Baseline and at 2 Months ] [ Designated as safety issue: No ]
|Study Start Date:||June 2013|
|Estimated Study Completion Date:||September 2014|
|Estimated Primary Completion Date:||September 2014 (Final data collection date for primary outcome measure)|
Experimental: Music Therapy Group Session
Participants will receive 60-minute group session twice a week over 2 months of period. Each session will be led by a music therapist. The contents of the music therapy session include drumming, rhythm imitation, score reading, lyrics comprehension, singing, and song discussion.
|Behavioral: Music Therapy Group Session|
No Intervention: No Music Therapy Session
Participants will receive pre- and post-assessments and evaluations at 0 and 2 months. No intervention will be provided. Music therapy sessions will be offered to participants in completion of their study participation.
Individuals with dementia often exhibit deterioration in cognitive functions and experience changes in emotions and personalities. Due to the changes in the frontal and temporal lobes of the brain, individuals with dementia often experience an impaired ability to judge situations. Empirical studies have indicated that cognitive stimulation is essential to facilitate individuals with dementia in thinking, concentration, and memory. Structured music activities provide cognitive stimulation to individuals with dementia through attentive listening and active participation. Additionally, drum improvisation not only reflects the current status of an individual, but also serves as an audio feedback through free play.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01958983
|Contact: Yu-Cheng Pei, PhD||886-3-3281200 ext firstname.lastname@example.org|
|Contact: Yen-Hsuan Yang, PhDemail@example.com|
|Chang Gung Medical Foundation||Recruiting|
|Taoyuan, Taiwan, 333|
|Contact: Yu-Cheng Pei, PhD 886-3-3281200 ext 3846 firstname.lastname@example.org|
|Principal Investigator:||Yu-Cheng Pei, PhD||Chang Gung Medical Foundation|