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Color Doppler Analysıs Of Uterin And Intraovarian Blood Flow Before And After Treatment Wıth Cabergoline In Hyperprolactinemic Patients

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01957839
Recruitment Status : Completed
First Posted : October 8, 2013
Last Update Posted : October 8, 2013
Information provided by (Responsible Party):
Osman Aşıcıoğlu, Istanbul Bakirkoy Maternity and Children Diseases Hospital

Brief Summary:
the investigators examined the hypothesis that hyperprolactinemia may alter uterin, endometrial and intraovarian blood flow and may contribute to increased infertility by another way.

Condition or disease Intervention/treatment Phase
Adverse Reaction to Other Drugs and Medicines Drug: cabergoline treatment Phase 4

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 48 participants
Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Study Start Date : March 2010
Actual Primary Completion Date : August 2011
Actual Study Completion Date : September 2011

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
No Intervention: pretreatment group
doppler evaluation at pretreatment period
Experimental: posttreatment group
doppler evaluatıon in normoprolactinemia women who given cabergoline treatment
Drug: cabergoline treatment
cabergoline treatment for hyperprolactinemia group

Primary Outcome Measures :
  1. th effect of prolactin vascular flow and resistance [ Time Frame: the effect of prolactin in vascular resistance at 2 weeks after treatment ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Women who had blood prolactin level higher than 25ng/dl

Exclusion Criteria:

  • Pregnancy
  • Use of drugs effecting vasculature such as hormonal therapy, oral contraceptives, antihypertensives
  • Diseases like pelvic inflammatory disease and systemic hypertension
  • Women with clinically overt or treated cardiovascular disease
  • Concurrent illness other than hyperprolactinemia

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01957839

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Sisli Etfal Teaching Hosital
Sisli, Turkey
Sponsors and Collaborators
Istanbul Bakirkoy Maternity and Children Diseases Hospital
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Principal Investigator: Osman Temizkan, M.D. SİSLİ ETFAL TEACHİNG HOSPİTAL

Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Osman Aşıcıoğlu, sisli etfal teaching hospital department gynecology and obstetric, Istanbul Bakirkoy Maternity and Children Diseases Hospital Identifier: NCT01957839     History of Changes
Other Study ID Numbers: Aşıcıoğlu-08
OA8 ( Other Identifier: Doppler )
First Posted: October 8, 2013    Key Record Dates
Last Update Posted: October 8, 2013
Last Verified: October 2013
Additional relevant MeSH terms:
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Antiparkinson Agents
Anti-Dyskinesia Agents
Dopamine Agonists
Dopamine Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs