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Individuals with insomnia have been shown to have higher overall metabolic rates compared to good sleepers, but it is not known which metabolic processes are involved. The goal of this study is to compare a wide array of metabolic processes in 15 people with insomnia and 15 good sleepers. We hypothesize that there will be distinct metabolic processes that are functioning differently in those with insomnia.
Number of Metabolites Elevated Relative to the Other Group. [ Time Frame: 48 hours ]
Metabolomics analysis of blood samples were carried out using Spectroscopy. This approach allows for rapid, unbiased and quantitative metabolic profiles ('fingerprints) to be acquired. A total of 70 metabolites were measured and compared between individuals with insomnia and good sleepers.
Secondary Outcome Measures
Sleep Efficiency Percentage on Overnight Sleep Study [ Time Frame: 1 night ]
Participants will have their sleep measured with polysomnography for one night. The sleep of individuals with insomnia will be compared to that of good sleepers. Sleep quality is defined as sleep efficiency, which is calculated at total sleep time / total time spent in bed x 100. It indicates the % of time spent asleep while in bed.
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Ages Eligible for Study:
25 Years to 55 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Individuals with primary insomnia (n=15) and matched good sleepers (n=15)
Criteria for primary insomnia:
subjective complaint of difficulty initiating or maintaining sleep, waking up too early or nonrestorative sleep
daytime consequences as a result of the poor sleep
duration of at least 1 month
sleep disturbance is not secondary to a medical or psychiatric condition
Criteria for good sleepers:
-subjective report of consistent good sleep
significant medical or psychiatric illness
diagnosis of a sleep disorder other than insomnia
women who have been pregnant or lactating in the past 6 months
non-fluency in spoken or written English
Current shift work defined as working during the evening or night shift