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Effects of Chiropractic Adjustments on Brain Function Using Quantitative Encephalography

This study has been completed.
Information provided by (Responsible Party):
Life University Identifier:
First received: August 23, 2013
Last updated: April 19, 2016
Last verified: April 2016

Despite the abundance of theories concerning the effects of chiropractic adjustments on brain function, this remains an understudies area for the profession.

Quantitative Electroencephalography (qEEG)is a technique that allows for an in-depth analysis of brain function. A normative database will be used to compare before, during and after effects of chiropractic adjustments on brain function. This will include usage of Low Resolution Electromagnetic Tomography (LORETA).

This study seeks to objectively document effects of chiropractic adjustments on brain function.

Condition Intervention
Brain Function
Other: Chiropractic adjustment
Other: Sham adjustment

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Participant)
Primary Purpose: Health Services Research
Official Title: Effects of Chiropractic Adjustments on Brain Function Using Quantitative Encephalography

Resource links provided by NLM:

Further study details as provided by Life University:

Primary Outcome Measures:
  • Changes in quantitative EEG values as compared to a normative database [ Time Frame: Baseline, during adjustment, after adjustment, follow up in 7 days ]

    There will be a baseline measurement. There will be measurements during the adjustment. There will be measurements immediately after the adjustment. There will be measurements 7 days after the adjustment.

    Data will then be analyzed comparing values to a normative database. This database is adjusted for age. This will generate z-score values in addition to raw EEG values. Statistical analysis of P-values will then be run to test significance of changes.

Secondary Outcome Measures:
  • Behavioral assessment questionaire [ Time Frame: At baseline, one week after adjustment. ]
    Subject will be asked to complete the Achenbach System of Empirically Based Assessment. This assessment asks questions about subjects adaptive and maladaptive functioning. This information is comparing the subject to other people their age.

Enrollment: 30
Study Start Date: June 2013
Study Completion Date: December 2015
Primary Completion Date: December 2015 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Sham Comparator: Placebo group
Ten people. Participants will receive what appears to be a chiropractic adjustment but which actually is not. This is the sham adjustment. Participants will also fill out Achenbach questionnaire. There will be a follow up in 7 days.
Other: Sham adjustment
Active Comparator: Chiropractic adjustment
Ten people. Group will be getting chiropractic adjustments. Participants will be filling out Achenbach questionnaire. There will be a follow up in 7 days.
Other: Chiropractic adjustment
No Intervention: Control group
Ten people. This group will simply have their EEG recorded at baseline and after 7 days. There will be an Achenbach questionnaire like the two other groups.


Ages Eligible for Study:   10 Years to 99 Years   (Child, Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Must be able to receive chiropractic adjustments

Exclusion Criteria:

  • No benzodiazepine class drugs in study participants
  • No use of medicines such as Sudafed (pseudoephedrine) or Nyquil (Doxylamine succinate)
  • At least 30 days since last chiropractic adjustment
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Please refer to this study by its identifier: NCT01953614

United States, Georgia
Life University
Marietta, Georgia, United States, 30060
Sponsors and Collaborators
Life University
  More Information

Responsible Party: Life University Identifier: NCT01953614     History of Changes
Other Study ID Numbers: I-0010
Study First Received: August 23, 2013
Last Updated: April 19, 2016

Keywords provided by Life University:
quantitative encephalography
brain computer interface
sacro-occipital technique processed this record on May 25, 2017