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Effect of Medium Chain Triglyceride Consumption on Appetite (MCT)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT01952977
Recruitment Status : Completed
First Posted : September 30, 2013
Last Update Posted : September 30, 2013
Information provided by (Responsible Party):
Marie-Pierre St-Onge, St. Luke's-Roosevelt Hospital Center

Brief Summary:
The purpose of this study is to test the effects of medium chain triglyceride consumption, relative to long chain triglycerides, on hormones involved in appetite regulation and food intake in overweight men. We expect medium chain triglycerides to reduce appetite and food intake and to do so by increasing levels of hormones known to be involved in satiety and reduce levels of those involved in appetite.

Condition or disease Intervention/treatment Phase
Obesity Dietary Supplement: Test breakfast Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 17 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Single (Participant)
Study Start Date : June 2010
Actual Primary Completion Date : August 2011
Actual Study Completion Date : August 2011

Arm Intervention/treatment
Active Comparator: MCT
MCT oil (20 g) was included in the test breakfast
Dietary Supplement: Test breakfast
Placebo Comparator: LCT
Corn oil (20 g) was included in the test breakfast
Dietary Supplement: Test breakfast

Primary Outcome Measures :
  1. Food intake [ Time Frame: up to 3 hours ]
    Intake at an ad libitum meal 3 h after test oil consumption (Study 1) or 1 h after a pre-load containing the test oil (Study 2)

Secondary Outcome Measures :
  1. Ghrelin [ Time Frame: 3 hours ]
  2. Peptide YY [ Time Frame: 3 hours ]
  3. Glucagon-like peptide 1 [ Time Frame: 3 hours ]
  4. Insulin [ Time Frame: 3 hours ]
  5. Triglycerides [ Time Frame: 3 hours ]
  6. Leptin [ Time Frame: 3 hours ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   19 Years to 50 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Males
  • Weight stable (<10 lb over previous 3 months)
  • Overweight (body mass index 25-29.9)

Exclusion Criteria:

  • Smokers
  • Excessive caffeine users
  • Severe health conditions
  • Allergy to food products/ingredients in the study
  • Taking medications known to affect energy expenditure or gastrointestinal function

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01952977

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United States, New York
New York Obesity Nutrition Research Center
New York, New York, United States, 10025
Sponsors and Collaborators
St. Luke's-Roosevelt Hospital Center
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Principal Investigator: Marie-Pierre St-Onge, Ph.D New York Obesity Nutrition Research Center
Publications automatically indexed to this study by Identifier (NCT Number):
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Responsible Party: Marie-Pierre St-Onge, Research Associate, St. Luke's-Roosevelt Hospital Center Identifier: NCT01952977    
Other Study ID Numbers: MCT_1
First Posted: September 30, 2013    Key Record Dates
Last Update Posted: September 30, 2013
Last Verified: September 2013