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Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Know the risks and potential benefits of clinical studies and talk to your health care provider before participating. Read our disclaimer for details. Identifier: NCT01949714
Recruitment Status : Recruiting
First Posted : September 24, 2013
Last Update Posted : May 24, 2019
Information provided by (Responsible Party):
Esben Søndergaard, University of Aarhus

Brief Summary:
  • To investigate the effect of catecholamine excess on brown fat.
  • To evaluate the effect of brown fat on energy expenditure and lipid and glucose metabolism

Condition or disease Intervention/treatment
Pheochromocytoma Adrenal Incidentaloma Procedure: Removal of adrenal tumor

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Study Type : Observational
Estimated Enrollment : 15 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Effect of Chronic Catecholamine Overproduction on Brown Adipose Tissue
Study Start Date : August 2013
Estimated Primary Completion Date : January 2022
Estimated Study Completion Date : January 2022

Group/Cohort Intervention/treatment
Pheochromocytoma patients
Pheochromocytoma patients
Procedure: Removal of adrenal tumor
Incidentaloma patients
Incidentaloma patients
Procedure: Removal of adrenal tumor

Primary Outcome Measures :
  1. [18F]FDG uptake in brown adipose tissue [ Time Frame: 3 months ]

Biospecimen Retention:   Samples With DNA
Blood and adipose tissue samples

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with adrenal tumors

Inclusion Criteria:

  • 10 patients with pheochromocytoma
  • 5 patients with incidentaloma without hormone production
  • Age > 18 years

Exclusion Criteria:

- None

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT01949714

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Contact: Esben Søndergaard, MD, PhD 4578461631

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Department of Endocrinology MEA, Aarhus Hospital Recruiting
Aarhus C, Please Select, Denmark, 8000
Contact    4578461631      
Principal Investigator: Esben Søndergaard, MD, PhD         
Sponsors and Collaborators
University of Aarhus

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Responsible Party: Esben Søndergaard, MD, PhD, Post Doc, University of Aarhus Identifier: NCT01949714     History of Changes
Other Study ID Numbers: ES-0005
First Posted: September 24, 2013    Key Record Dates
Last Update Posted: May 24, 2019
Last Verified: May 2019
Additional relevant MeSH terms:
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Adrenocortical Adenoma
Neuroendocrine Tumors
Neuroectodermal Tumors
Neoplasms, Germ Cell and Embryonal
Neoplasms by Histologic Type
Neoplasms, Nerve Tissue
Adrenal Cortex Neoplasms
Adrenal Gland Neoplasms
Endocrine Gland Neoplasms
Neoplasms by Site
Adrenal Cortex Diseases
Adrenal Gland Diseases
Endocrine System Diseases
Epinephryl borate
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Adrenergic beta-Agonists
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Anti-Asthmatic Agents