Clinical Immunization Safety Assessment (CISA) Project: Pilot Study to Assess the Effect of Prophylactic Antipyretics on Immune Responses and Fever After IIV

• ClinicalTrials.gov Identifier: NCT01946594
• Recruitment Status: Completed
• First Posted: September 19, 2013
• Last Update Posted: January 20, 2016
• Sponsor: Duke University
• Collaborator: Centers for Disease Control and Prevention
• Information provided by (Responsible Party): Duke University

Study Description

Brief Summary:

The study team aims to conduct a double-blind, placebo-controlled, pilot study to assess the effect of prophylactic antipyretics on the immune responses and rates of fever after inactivated influenza vaccine (IIV) in children 12 through 35 months of age. In this pilot, 40 healthy children, 12 through 35 months of age, including some children at risk of febrile seizure, will be randomized to receive prophylactic acetaminophen or oral placebo immediately following and every 4 to 6 hours in the 24 hours after receipt of a dose of IIV. Data derived from the pilot study will be used to assess the feasibility of conducting a larger scale study. Feasibility will include assessments of the speed and ease of study recruitment and adherence to and completion of study assessments. Children will be followed for the occurrence of fever, fussiness, changes in appetite and sleep patterns, and use of medical services on the day of and day following vaccination. Antibody to influenza antigens contained in the 2013-2014 vaccine as measured by hemagglutination inhibition (HAI) antibody will be assessed at baseline and four weeks following vaccination. The proportions of children experiencing fever, having solicited reactions, using medical services, demonstrating a serologic response corresponding to seroprotection and seroconversion to each of the IIV antigens will be determined for groups of children receiving acetaminophen and placebo. Likewise geometric mean HAI titers (GMT) and corresponding 95% confidence intervals for each IIV antigen will be calculated for both vaccine groups.

Condition or disease	Intervention/treatment	Phase
Fever	Other: Acetaminophen; Other: Placebo	Phase 4

Study Design

• Study Type: Interventional (Clinical Trial)
• Actual Enrollment: 41 participants
• Allocation: Randomized
• Intervention Model: Parallel Assignment
• Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
• Primary Purpose: Prevention
• Official Title: Pilot Study to Assess the Effect of Prophylactic Antipyretics on Immune Responses and Rates of Fever After 2013-2014 Inactivated Influenza Vaccine (IIV) in Young Children
• Study Start Date: October 2013
• Actual Primary Completion Date: March 2014
• Actual Study Completion Date: March 2014

Arms and Interventions

Arm	Intervention/treatment
Active Comparator: Acetaminophen Arm; Acetaminophen Suspension 160 mg / 5 mL: Oral dose immediately following IIV and every 4-6 hours up to 24 hours (Maximum 5 oral doses)	Other: Acetaminophen
Placebo Comparator: Placebo Arm; Placebo Suspension: Oral dose immediately following IIV and every 4-6 hours up to 24 hours (Maximum 5 oral doses)	Other: Placebo

Outcome Measures

Primary Outcome Measures :

1. Completion of study procedures [ Time Frame: 1 month ]
   Percent of participants for whom study procedures were completed successfully (prophylactic medication administered, temperature measured, memory aid completed, venipunctures performed)

Secondary Outcome Measures :

1. Immune Response to IIV [ Time Frame: 1 month ]
   Immune responses (hemagglutination inhibition assay) to IIV in each group (proportion of subjects demonstrating seroprotection and seroconversion and geometric mean titer)

Other Outcome Measures:

1. IIV reactogenicity and use of medical care services [ Time Frame: 2 days ]
   Proportion of subjects in each group with fever, fussiness, change in appetite or sleep patterns, and receipt of medical attention

Eligibility Criteria

• Ages Eligible for Study: 12 Months to 35 Months (Child)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: Yes

Criteria

Inclusion Criteria:

To be eligible for inclusion in the study the following enrollment criteria must be met:

1. The child must be 12 through 35 months of age.
2. The child must only need a single dose of IIV during the current season. (Children only need 1 dose of vaccine in 2013-14 if they received a total of 2 or more doses of seasonal vaccine since July 1, 2010. Children who did not receive a total of 2 or more doses of seasonal vaccine since July 1, 2010 require 2 doses in 2013-14).[19]
3. The parent/guardian must be willing and capable of providing written informed consent for the child.
4. The parent/guardian must be available for follow-up and must at minimum have telephone access.
5. The parent/guardian must agree to sign a medical release for the child so that study personnel may obtain medical information about the child's health (if needed).

Exclusion Criteria:

Participants must not have any of the following:

1. History of receipt of current year's licensed influenza vaccine.
2. History of a severe allergic reaction (e.g. anaphylaxis) to any component of influenza vaccine, including egg protein, formaldehyde, octylphenol ethoxylate, gelatin, or thimerosal if using thimerosal containing vaccine.
3. History of a severe allergic reaction (e.g. anaphylaxis) following a prior dose of influenza vaccine.
4. History of an allergic reaction following acetaminophen or ingredients in the acetaminophen product.
5. History of an allergic reaction following ibuprofen or ingredients in the ibuprofen product.
6. History of liver disease.
7. Currently taking the blood thinning drug warfarin (Coumadin).
8. Received any other licensed vaccines within 14 days (for inactivated vaccines) or 28 days (for live vaccines) prior to vaccination in this study or expects to receive a licensed vaccine during the 28 days following the last vaccination in this study. Concomitant vaccinations are not allowed.
9. Routine immunizations are delayed or will be delayed by not being able to receive a concomitantly administered vaccine or a needed vaccine in the 28 days following receipt of the influenza vaccine.
10. Received an experimental/investigational agent (vaccine, drug, biologic, device, blood product, or medication) within 28 days prior to vaccination in this study, or expects to receive an experimental/investigational agent within the follow-up time period (28 days after the last vaccination in this study).
11. A moderate to severe acute illness and/or a reported temperature greater than or equal to 100.0°F (37.8°C) within 72 hours prior to first dose of IIV or an axillary temperature greater than or equal to 100.0°F (37.8°C) at the time of enrollment. (This may result in a temporary delay of vaccination).
12. Receipt of an antipyretic medication (acetaminophen or ibuprofen) within 72 hours prior to the first dose of IIV (This may result in a temporary delay of vaccination) or is already planning to administer a prophylactic antipyretic medication on the day of and the day following IIV (this exclusion does not apply if the caretaker indicates he/she might administer antipyretics after vaccination to reduce a fever).
13. Immunosuppression as a result of an underlying illness or treatment, or use of anti-cancer chemotherapy or radiation therapy within the preceding 36 months.
14. Long term (at least 14 days of prednisone 2 mg/kg/day or equivalent other glucocorticoid), any parenteral steroids, high-dose inhaled steroids (>800 mcg/day of beclomethasone dipropionate or equivalent) within the preceding 6 months (topical and nasal steroids are allowed).
15. History of Guillain-Barré syndrome within 6 weeks of a prior dose of influenza vaccine.
16. Has any condition that would, in the opinion of the site investigator, place the participant at an unacceptable risk of injury or render the participant unable to meet the requirements of the protocol.

Contacts and Locations

Locations

United States, North Carolina

Duke University Health System

Durham, North Carolina, United States, 27710

Sponsors and Collaborators

Duke University

Centers for Disease Control and Prevention

Investigators

• Principal Investigator: Emmanuel B Walter, MD; Duke University
• Principal Investigator: Karen Broder, MD; Centers for Disease Control and Prevention

More Information

• Responsible Party: Duke University
• ClinicalTrials.gov Identifier: NCT01946594
• Other Study ID Numbers: Pro00048541; 200-2012-53663 ( Other Grant/Funding Number: Centers for Disease Control and Prevention )
• First Posted: September 19, 2013
• Last Update Posted: January 20, 2016
• Last Verified: January 2016

Keywords provided by Duke University:

fever; antipyretics; acetaminophen; influenza vaccine; influenza, human; body temperature changes; Orthomyxoviridae Infections; RNA virus infections; Virus Diseases; Respiratory Tract Infections; Respiratory Tract Diseases

Additional relevant MeSH terms:

Fever; Body Temperature Changes; Acetaminophen; Analgesics, Non-Narcotic; Analgesics; Sensory System Agents; Peripheral Nervous System Agents; Physiological Effects of Drugs; Antipyretics