The Association With Peptic Ulcer Disease and Hepatic Vein Pressure Gradient
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|ClinicalTrials.gov Identifier: NCT01944878|
Recruitment Status : Completed
First Posted : September 18, 2013
Results First Posted : July 24, 2014
Last Update Posted : July 24, 2014
|Condition or disease|
|Cirrhosis Chronic Liver Disease|
Retrospective case-control study
- Investigators will analyze the medical records of hepatic vein pressure gradient (HVPG) and esophagogastroduodenoscopy (EGD) cases who had liver cirrhosis (LC) or chronic hepatitis in a single tertiary hospital (Chuncheon Sacred Heart hospital, Korea) within 2008~2012.
- Portal hypertension is assessed using HVPG measurement via transjugular approach.
- Peptic ulcer is evaluated through EGD within 3 months of HVPG measurement
- The association of Peptic ulcer with LC, chronic hepatitis and total population (LC or chronic hepatitis) will be assessed by univariate and multivariate analysis
- There is no specific time frame, because this study is retrospective observational study, however EGD data is enrolled if it was done within 3 month from HVPG measurement.
|Study Type :||Observational|
|Actual Enrollment :||455 participants|
|Observational Model:||Case Control|
|Official Title:||Retrospective Observational Study of Impact of Portal Hypertension for the Peptic Ulcer in Liver Cirrhosis and Chronic Hepatitis|
|Study Start Date :||May 2013|
|Actual Primary Completion Date :||August 2013|
|Actual Study Completion Date :||August 2013|
Patients with chronic hepatitis
Patients with chronic hepatitis, who experienced HVPG measurement via transjugular approach and EGD within 3 months of HVPG measurement
Patients with liver cirrhosis
Patients with liver cirrhosis, who experienced HVPG measurement via transjugular approach and EGD within 3 months of HVPG measurement
- The Association of HVPG and PUD in Patients With Liver Cirrhosis [ Time Frame: Retrospective case-control study (from 2009 to 2012, up to 3 years) ]
The association of hepatic vein pressure gradient that reflects portal hypertension and peptic ulcer disease in patients with liver cirrhosis was assessed statistically.
(NO specific time frame, only confined to 2009 to 2012, when the HVPG measurement was done). The Mann-Whitney test was used to evaluate the association between PUD or not and HVPG degree, by SPSS software.
- The Association Between PUD and HVPG in Patients With Chronic Hepatitis [ Time Frame: Retrospective case-control study (from 2009 to 2012, up to 3 years) ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01944878
|Korea, Republic of|
|Chuncheon Sacred Heart hospital|
|Chuncheon, Gangwon-do, Korea, Republic of, 200-704|
|Principal Investigator:||Chang Seok Bang, M.D||Department of Internal Medicine, Hallym University College of Medicine|
|Study Chair:||Gwang Ho Baik, M.D||Department of Internal Medicine, Hallym University College of Internal Medicine|