Carnitine, Aclycarnitine, Myocardial Function, and CRRT
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|ClinicalTrials.gov Identifier: NCT01941823|
Recruitment Status : Recruiting
First Posted : September 13, 2013
Last Update Posted : January 30, 2019
|Condition or disease|
|Acute Renal Failure|
|Study Type :||Observational|
|Estimated Enrollment :||30 participants|
|Official Title:||Pilot Study: Effect of Carnitine Supplementation on Acylcarnitine Profile and Myocardial Function in Children and Young Adults Receiving Continuous Renal Replacement Therapy|
|Study Start Date :||December 2014|
|Estimated Primary Completion Date :||October 2019|
|Estimated Study Completion Date :||January 2020|
Carnitine CRRT, prospective
CRRT patients given carnitine in TPN as part of clinical protocol. Will evaluate total and free, carnitine and acylcarnitine profile as well as cardiac function by standard and speckle tracking echo weekly during CRRT.
CRRT Control, retrospective
Retrospective control group, CRRT patients who did not receive carnitine supplementation during CRRT and had carnitine levels measured and echo performed during CRRT.
ICU Control (non-CRRT), prospective
Critically ill ICU patients not receiving any exogenous carnitine, and not receiving CRRT, will have total and free carnitine and acylcarnitine profile measured weekly during CRRT.
- Cardiac function of children receiving carnitine compared with controls during CRRT [ Time Frame: 1-3 weeks ]Echocardiography parameters of children in the study group will be compared to those of the retrospective CRRT control group.
- Carnitine deficiency in children receiving CRRT [ Time Frame: Baseline ]Total and free carnitine levels and acylcarnitine profile of the 3 study cohorts will be compared with published normal levels in children.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01941823
|Contact: Asha Moudgil, MDemail@example.com|
|Contact: Kristen Sgambat, MS RDfirstname.lastname@example.org|
|United States, District of Columbia|
|Children's National Medical Cetner||Recruiting|
|Washington, District of Columbia, United States, 20010|
|Contact: Asha Moudgil, MD email@example.com|
|Principal Investigator: Asha Moudgil, MD|
|Principal Investigator:||Asha Moudgil, MD||Children's Research Institute|