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The Influence of Oxytocin on the Processing of Social Contact

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ClinicalTrials.gov Identifier: NCT01939639
Recruitment Status : Completed
First Posted : September 11, 2013
Last Update Posted : September 11, 2013
Sponsor:
Information provided by (Responsible Party):
Rene Hurlemann, University Hospital, Bonn

Brief Summary:
Social touch can convey the most potent and salient of socio-emotional signals. While the hypothalamic peptide oxytocin (OXT) has been identified as a key neurochemical mediator of grooming in some other social species, its modulatory influence on human interpersonal touch is unknown. The investigators expect that OXT augments the hedonic value of touch and that this behavioral effect is paralleled at the neural level by an increased response in brain areas mediating rewarding aspects of social touch.

Condition or disease Intervention/treatment Phase
Healthy Male Volunteers Drug: Placebo Drug: Oxytocin Phase 1

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 40 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Study Start Date : March 2013
Actual Primary Completion Date : June 2013
Actual Study Completion Date : August 2013

Resource links provided by the National Library of Medicine

Drug Information available for: Oxytocin

Arm Intervention/treatment
Experimental: Oxytocin
24 IU Oxytocin, intranasal application 30 min prior to the experiment
Drug: Oxytocin
24 IU Oxytocin, intranasal application 45 min prior to the experiment
Other Name: Syntocinon

Placebo Comparator: Placebo
intranasal application, sodium chloride solution, 3 puffs per nostril
Drug: Placebo
intranasal application, sodium chloride solution, 3 puffs per nostril




Primary Outcome Measures :
  1. Pleasantness ratings of social touch [ Time Frame: 30 minutes after the nasal spray administration ]
    After each trial, subjects are asked to use a visual analog scale to rate the pleasantness of the administered touch.

  2. Blood-oxygen-level dependent signal in response to social touch [ Time Frame: 30 minutes after the nasal spray administration ]
    By using functional magnetic resonance imaging we want to examine oxytocin's effects on the neural correlates (BOLD signal) of social touch.


Secondary Outcome Measures :
  1. Questionnaire measurement of mood (PANAS) and anxiety (STAI). [ Time Frame: 15 minutes before the nasal spray administration and (on average) 10 minutes after the fMRI experiment ]

Other Outcome Measures:
  1. Saliva oxytocin concentrations [ Time Frame: 15 minutes before the nasal spray administration and (on average) 10 minutes after the fMRI experiment ]


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Ages Eligible for Study:   18 Years to 60 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

Healthy male volunteers

Exclusion Criteria:

Current or past psychiatric disease Current or past physical illness Psychoactive medication Tobacco smokers


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01939639


Locations
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Germany
Department of Psychiatry, University of Bonn
Bonn, North Rhine-Westphalia, Germany, 53105
Sponsors and Collaborators
University Hospital, Bonn

Additional Information:
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Responsible Party: Rene Hurlemann, MD PhD M.Sc., University Hospital, Bonn
ClinicalTrials.gov Identifier: NCT01939639     History of Changes
Other Study ID Numbers: OXT_PS_2013
PS_2013 ( Other Grant/Funding Number: University of Bonn )
First Posted: September 11, 2013    Key Record Dates
Last Update Posted: September 11, 2013
Last Verified: September 2013
Keywords provided by Rene Hurlemann, University Hospital, Bonn:
Oxytocin
fMRI
Additional relevant MeSH terms:
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Oxytocin
Oxytocics
Reproductive Control Agents
Physiological Effects of Drugs