Use of Tinzaparin for Anticoagulation in Hemodialysis (HEMO-TIN)
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The HEMO-TIN trial is designed to look at both the safety (bleeding risk) and effectiveness (clotting risk) of tinzaparin compared with unfractionated heparin for anticoagulation in hemodialysis patients.
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Ages Eligible for Study:
18 Years and older (Adult, Senior)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Age >= 18 years
End stage renal disease maintained on outpatient hemodialysis for >= 3 months
Frequency of hemodialysis: 3 times per week
Anticoagulation with an unfractionated heparin protocol for at least 4 weeks
Patient or legal guardian able to provide written consent
Baseline INR <= 1.3
Baseline platelet count >= 80,000 x 10^9/L
Therapeutic systemic anticoagulation
Clinically apparent bleeding in the last 2 months
High risk of bleeding
Planned major surgery in the next 4 months
Major surgery in the past 48 hours
Pregnant or lactating
Child bearing potential
Allergy/intolerance to heparin or history of heparin induced thrombocytopenia
Current participation in a related randomized drug trial