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Effectiveness of Silver Nitrate Solution in the Treatment of Anal Fistula

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified August 2013 by M.Umit UGURLU, Marmara University.
Recruitment status was:  Recruiting
Information provided by (Responsible Party):
M.Umit UGURLU, Marmara University Identifier:
First received: August 19, 2013
Last updated: August 22, 2013
Last verified: August 2013
Effectiveness of silver nitrate solution in treatment of anal fistula is is aimed to be investigated.

Anal Fistula

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Effectiveness of Silver Nitrate Solution in the Treatment of Anal Fistula: A Novel Strategy for Managing Anal Fistula

Resource links provided by NLM:

Further study details as provided by M.Umit UGURLU, Marmara University:

Primary Outcome Measures:
  • Number of anal fistula patients treated with silver nitrate solution. [ Time Frame: 1 year ]
    The primary end point in the study was to assess the efficacy of the silver nitrate in the treatment of anal fistula. The number of anal fistula patients who are treated with silver nitrate solution will be calculated. The role of silver nitrate solution in anal fistula treatment will be investigated

Secondary Outcome Measures:
  • Therapeutic factors [ Time Frame: 1 year ]
    The secondary end point was to identify the clinical and therapeutic factors that significantly affect the primary endpoint.

Estimated Enrollment: 70
Study Start Date: August 2013
Estimated Study Completion Date: March 2014
Estimated Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Silver Nitrate
Irrigation of fistula tract with 1% silver nitrate solution for all patients who accepts the study and signed the written informed consent form.

Detailed Description:
The anal fistula is a granulation tissue-lined tract, we thought of a way to ablate this granulation tissue using a chemical agent, which would eventually induce healing with fibrosis and closure of the tract without any surgical intervention. Aiming to reduce the surgery related complications; we investigated the effectiveness of silver nitrate solution as a chemical agent in the treatment of anal fistula.

Ages Eligible for Study:   18 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients with the diagnosis of anal fistula

Inclusion Criteria:

All patients with the diagnosis of anal fistula Patients with recurrence

Exclusion Criteria:

Patients who do not sign the informed consent

  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT01929525

MarmaraUSM Recruiting
Istanbul, Turkey, 34893
Contact: M.Unit Ugurlu, MD    +905324108010   
Sub-Investigator: M.Umit Ugurlu, MD         
Sponsors and Collaborators
Marmara University
Study Chair: S.CUMHUR YEGEN, MD Marmara University
  More Information

Responsible Party: M.Umit UGURLU, Assistant profesor of surgery, Marmara University Identifier: NCT01929525     History of Changes
Other Study ID Numbers: MarmaraUSM
Study First Received: August 19, 2013
Last Updated: August 22, 2013

Additional relevant MeSH terms:
Rectal Fistula
Pathological Conditions, Anatomical
Intestinal Fistula
Digestive System Fistula
Digestive System Diseases
Intestinal Diseases
Gastrointestinal Diseases
Rectal Diseases
Silver Nitrate
Anti-Infective Agents, Local
Anti-Infective Agents processed this record on August 22, 2017