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Trial of Anti-PSMA Designer T Cells in Advanced Prostate Cancer After Non-Myeloablative Conditioning

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ClinicalTrials.gov Identifier: NCT01929239
Recruitment Status : Suspended (Funding)
First Posted : August 27, 2013
Last Update Posted : June 17, 2016
Sponsor:
Information provided by (Responsible Party):
Roger Williams Medical Center

Brief Summary:
This is a Phase Ib Pilot study of anti-PSMA designer T cells in metastatic prostate cancer. Subjects will receive escalating doses of T cells, with either low or moderate dose Interleukin 2. The T cells are collected by pheresis and then genetically modified, and given in a one time infusion.

Condition or disease Intervention/treatment Phase
Monitor Adverse Events Drug: Anti-PSMA Designer T Cells Phase 1 Phase 2

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 12 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Phase Ia/Ib Trial of Anti-PSMA Designer T Cells in Prostate Cancer After Non-Myeloablative Conditioning
Study Start Date : March 2006
Estimated Primary Completion Date : December 2017
Estimated Study Completion Date : December 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Prostate Cancer

Arm Intervention/treatment
Experimental: Anti PSMA Designer T Cells
Open Label, subjects receive anti PSMA designer T cells, plus IL2, low or moderate dose.
Drug: Anti-PSMA Designer T Cells



Primary Outcome Measures :
  1. Number of participants with adverse events [ Time Frame: 30 days ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

5.2.1 Patient with histologically confirmed diagnosis of prostate cancer.

5.2.2 Patient with rising serum PSA,(prostate specific antigen).

5.2.3 Tumor is hormone refractory, as documented by rising PSA with two values separated in time. Patients may enroll if they have a rising PSA after withdrawal of androgen therapy but if enrolled onto this protocol on androgen ablation therapy, they must remain on the androgen therapy for the duration of this protocol. Patients may enroll if tumor is not hormone refractory only if they refuse hormone therapy at this time, and that they understand that hormone therapy is standard treatment for their disease at this stage.

5.2.4 Patient must be at least 18 years of age.

5.2.5 Patient able to understand and sign informed consent.

5.2.6 Patient with a life expectancy of greater than four months.

5.2.7 Patient with performance status of 0 to 1. (http://www.ecog.org/general/perf_stat.html).

5.2.8 Patient with adequate organ function as defined by:

5.2.8.1 ANC 1.0, platelets 50,000, Hgb 8.0; patient may be transfused to achieve Hgb 8.0 to satisfy enrollment criteria, or as otherwise indicated by symptoms for Hgb >8.0.

5.2.8.2 Creatinine 1.5mg/dl or creatinine clearance 60cc/min.

5.2.8.3 Direct bilirubin 1.5 mg/dl.

5.2.8.4 No evidence of congestive heart failure, symptoms of coronary artery disease, serious cardiac arrhythmias, including atrial fibrillation/atrial flutter, evidence of prior myocardial infarction by history or EKG. A normal cardiac stress test for inducible ischemia or arrhythmia within 12 weeks prior to enrollment for all patients over 50 years old or those with abnormal EKG or any history or symptoms suggestive of cardiac disease.

5.2.8.5 No serious, symptomatic obstructive or emphysema¬tous lung disease, or asthma requiring intravenous medications within the past 12 months; no serious lung disease associated with dyspnea at normal activity levels (grade III) or at rest (grade IV), due to any cause (including cancer metastases and pleural effusions). The patient will be ineligible if PFTs show an FEV1 <1.3 liters or a DLCO <50% within 12 weeks of study entry.

For patients enrolling in cohorts IIA, IIB, and III:

5.2.9 Patients with disease in the bone or other site(s) have biopsy-able tumor (at radiologically- or externally-accessible site), and willing to undergo biopsy as specified in 6.3.6. For these groups, patients with >5 lesions bone scan positive lesions will be preferred to increase the yield of blind bone marrow biopsies.

Alternatively, patients with bone or extra-skeletal lesions may be biopsied by CT guided or open procedure.

Exclusion Criteria:

5.3.1 Patients with serious or unstable renal, hepatic, pulmonary, cardiovascular, endocrine, rheumatologic, or allergic disease based on history, physical exam and laboratory tests will be excluded, as outlined in section 5.2.9.

5.3.2 Patients with active clinical disease caused by CMV, hepatitis B or C, HIV or tuberculosis will be excluded from the study.

5.3.3 Patients who have had cytotoxic and/or radiation therapy in the four weeks prior to entry or who have initiated anti-androgen therapy less than six weeks prior to entry will be excluded.

5.3.4 Patients with other concurrent malignancies will be excluded.

5.3.5 Patients requiring systemic steroids will be excluded.

5.3.6 Patients with prior investigational therapies within the 4 weeks prior to entry will be excluded.

5.3.7 Patients previously exposed to mouse antibody will be excluded, unless proven by ELISA to have a negative baseline human anti-mouse antibody (HAMA) titer.

5.3.8 Patients who have had irradiation to whole pelvis or to more than 25% of total marrow will be excluded.


Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01929239


Locations
United States, Rhode Island
Roger Williams Medical Center
Providence, Rhode Island, United States, 02908
Sponsors and Collaborators
Roger Williams Medical Center
Investigators
Principal Investigator: Richard P Junghans, PhD, MD Roger Williams Medical Center

Responsible Party: Roger Williams Medical Center
ClinicalTrials.gov Identifier: NCT01929239     History of Changes
Other Study ID Numbers: W81XWH-05-1-0408
First Posted: August 27, 2013    Key Record Dates
Last Update Posted: June 17, 2016
Last Verified: June 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided

Additional relevant MeSH terms:
Prostatic Neoplasms
Genital Neoplasms, Male
Urogenital Neoplasms
Neoplasms by Site
Neoplasms
Genital Diseases, Male
Prostatic Diseases