BAP1 Testing in Instance Choroidal Nevi or Uveal Melanoma
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The BAP1 trial will examine the blood of patients diagnosed with choroidal nevi or uveal melanoma for a germline BAP1 mutation and other genetic markers associated with developing malignancy as well as additional sequencing of the uveal melanoma genome.
Condition or disease
Choroidal Nevi, Uveal Melanoma
A germline BAP1 mutation predisposes a person to developing uveal melanoma and other cancers. If a mutation is discovered, it changes the potential approach to managing the nevus. In the presence of a known genomic change associated with aggressive disease, closer follow up and more aggressive treatment could preserve the patient's vision and prevent micrometastatic spread. This new screening technique will be able to extend the length and quality of life of patients with more frequent targeted cancer screens.
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Patients age > 18 years, diagnosed with choroidal nevi or uveal melanoma
any person with choroidal nevi
Willingness to provide signed informed consent
Age > 18 years
Diagnosis of choroidal nevi or uveal melanoma
Threre are no exclusionary criteria for this study.