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Microcirculatory Assessment in Patients With Trauma and Severe Burns

This study is ongoing, but not recruiting participants.
Information provided by (Responsible Party):
William Richards, University of South Alabama Identifier:
First received: June 27, 2013
Last updated: January 27, 2016
Last verified: January 2016
Predict the development of multiple organ failure in patients with trauma and severe burns.

Condition Intervention
Other: micro-imaging

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Microcirculatory Assessment in Patients With Trauma and Severe Burns

Resource links provided by NLM:

Further study details as provided by University of South Alabama:

Primary Outcome Measures:
  • dysfunctional capillary density correlates with development of multiple organ failure [ Time Frame: approximately 1 year to assess outcome measure ]

Estimated Enrollment: 200
Study Start Date: April 2012
Estimated Study Completion Date: December 2016
Estimated Primary Completion Date: December 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions

Sublingual or subconjunctival micro-imaging of the microcirculation taken for 3 minute intervals at certain timepoints.

Timepoints for burn/trauma subjects: Day0, Day1,Day2,Day6 & Day7 Timepoints for general surgery population: post-induction, prior to resection, after resection,& closing of surgical wound.

Other: micro-imaging

Detailed Description:

Microvascular alterations are frequently seen in patients with sepsis, trauma, burns and those who are hemodynamically uncompensated(Shock).

The use of the Microscan is a non-invasive approach to visualize and assess impaired mucosal microcirculation in order to identify early on patients who are predisposed for MOF (multiple organ failure)


Ages Eligible for Study:   19 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with severe burns/trauma ages 19-80. Patients undergoing elective abdominal or cardiothoracic surgery ages 19-69 years old

Exclusion Criteria:

  • Patients undergoing elective surgery < 19 years old.
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Please refer to this study by its identifier: NCT01922960

United States, Alabama
University of South Alabama Medical Center
Mobile, Alabama, United States, 36617
Sponsors and Collaborators
University of South Alabama
Study Chair: William O Richards, MD University of South Alabama, Department of Surgery
  More Information

Responsible Party: William Richards, Study Chair and Principle Investigator, University of South Alabama Identifier: NCT01922960     History of Changes
Other Study ID Numbers: 12-092
Study First Received: June 27, 2013
Last Updated: January 27, 2016

Keywords provided by University of South Alabama:
multiple organ dysfunction syndrome

Additional relevant MeSH terms:
Wounds and Injuries
Burns processed this record on May 25, 2017