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Identification Sepsis Related Single Nucleotide Polymorphism (SNP) by Whole Exome Sequencing

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ClinicalTrials.gov Identifier: NCT01920217
Recruitment Status : Unknown
Verified August 2013 by Huijuan Wang, Chinese PLA General Hospital.
Recruitment status was:  Recruiting
First Posted : August 9, 2013
Last Update Posted : August 9, 2013
Sponsor:
Information provided by (Responsible Party):
Huijuan Wang, Chinese PLA General Hospital

Brief Summary:
Sepsis is a common cause of death in intensive care unit, timely and accurate diagnosis and treatment directly affect the survival rate. Single nucleotide polymorphism (SNP) was promising genetic biomarker for sepsis patients. The present study was designed to screen several SNP by whole exome sequencing which evaluate the sepsis related snp site in order to be a new target for the treatment of sepsis.

Condition or disease
Sepsis

Detailed Description:
The study is a non-intervention, prospective observational study. Purpose of this sudy is to screening several SNPs by whole exome sequencing which can be used as genetic marker for sepsis patients. We will collect whole blood samples from patients with sepsis inRespiratory Intensive Care Unit (RICU), the Emergency Intensive Care Unit (EICU), or the Department of Surgery's ICU 301 Hospital since January 2013, and then whole exome sequencing was used to Screen SNPs which were related to sepsis. Then another 500 sepsis patients and 500 normal controls were used to validated the sequencing results.

Study Type : Observational [Patient Registry]
Estimated Enrollment : 1000 participants
Observational Model: Case Control
Time Perspective: Prospective
Target Follow-Up Duration: 28 Days
Official Title: Identification Sepsis Related SNP by Whole Exome Sequencing: a Prospective Observational Study
Study Start Date : January 2013
Estimated Primary Completion Date : January 2015
Estimated Study Completion Date : December 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Sepsis

Group/Cohort
normal control
Sepsis group



Primary Outcome Measures :
  1. sepsis related SNP site [ Time Frame: 28 days after admitted to ICU ]

Biospecimen Retention:   Samples With DNA
whole blood sample


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
within 24 hours after admited in ICU
Criteria

Inclusion Criteria:

  • Clinical diagnosis of sepsis
  • Patients who agree with the study

Exclusion Criteria:

  • Aged <18 years;
  • Into the group who died within 24 hours;
  • Agranulocytosis (<0.5 × 109 / L);
  • Combined HIV infection.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT01920217


Contacts
Contact: Huijuan Wang, Dr +86 13466791738 wanghuijuan301@gmail.com

Locations
China, Beijing
Chinese PLA general hospital Recruiting
Beijing, Beijing, China, 100086
Contact: lixin xie, Dr    +86 1068185281    xielx@263.net   
Sponsors and Collaborators
Chinese PLA General Hospital
Investigators
Study Director: Huijuan Wang, Dr Chinese PLA General Hospital

Responsible Party: Huijuan Wang, Dr, Chinese PLA General Hospital
ClinicalTrials.gov Identifier: NCT01920217     History of Changes
Other Study ID Numbers: 301PLAGH20130610
First Posted: August 9, 2013    Key Record Dates
Last Update Posted: August 9, 2013
Last Verified: August 2013

Keywords provided by Huijuan Wang, Chinese PLA General Hospital:
sepsis
SNP
mortality

Additional relevant MeSH terms:
Sepsis
Toxemia
Infection
Systemic Inflammatory Response Syndrome
Inflammation
Pathologic Processes